OSTF1 and SYNGAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OSTF1	SYNGAP1
Description		osteoclast stimulating factor 1	synaptic Ras GTPase activating protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Cytosol Plasma Membrane Postsynaptic Density Membrane Dendritic Shaft Glutamatergic Synapse
	Molecular Function	Protein Binding SH3 Domain Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Ossification Signal Transduction	Ras Protein Signal Transduction Pattern Specification Process Axonogenesis Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Modulation Of Chemical Synaptic Transmission Neuron Apoptotic Process Maintenance Of Postsynaptic Specialization Structure Regulation Of Intracellular Signal Transduction
Pathways		Neutrophil degranulation	Regulation of RAS by GAPs
Drugs
Diseases			Non-syndromic autosomal dominant mental retardation
GWAS		Allergic rhinitis ( 25085501) Glucose homeostasis traits ( 25524916) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Resting-state electroencephalogram vigilance ( 29703947) Systemic sclerosis ( 30247649) Urinary magnesium-to-creatinine ratio ( 29093028)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		51 interacting genes: AGR2 APP BORCS6 CBL CBLB CCDC33 CRX CTDSP1 CUEDC1 DPPA4 DTX3 EFS ERRFI1 FASLG FBXO7 GAPDH GGN HES7 HTT KHDRBS1 KLHL42 LATS1 LMNA MAPK6 MED19 MEOX2 NFYC NUTM1 NUTM2F PBX4 PICK1 PRRG4 REL SDCBP SF1 SF3A2 SMN1 SNW1 SOCS7 SYNGAP1 TRIB3 TRIM54 VPS37B WASF1 WASHC1 WASL YPEL3 ZBTB42 ZBTB7B ZNF655 ZNF688	32 interacting genes: CAMK2A CRK DLG3 DLG4 DLGAP4 DSCAM EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR LCOR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX
Entrez ID		26578	8831
HPRD ID		17808	16018
Ensembl ID		ENSG00000134996	ENSG00000197283
Uniprot IDs		Q92882	A0A1U9X8L0 B7ZCA0 Q96PV0
PDB IDs		1X2K 1ZLM 3EHQ 3EHR
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor-mediated Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway SH3 Domain Binding Regulation Of ERBB Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Synapse Structure Or Activity Regulation Of Receptor Internalization Nucleus Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway MRNA 3'-splice Site Recognition Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Transcription By RNA Polymerase II Establishment Of Organelle Localization Regulation Of Actin Nucleation Neuron Projection Organization Cytoskeleton-dependent Intracellular Transport Regulation Of Endocytosis Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Localization Spliceosomal Complex Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Arp2/3 Complex Binding Regulation Of Supramolecular Fiber Organization Regulation Of Metabolic Process Regulation Of Plasma Membrane Organization Negative Regulation Of Alpha-beta T Cell Proliferation Localization Within Membrane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endocytosis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Glutamate Binding Postsynaptic Density Positive Regulation Of Synaptic Transmission, Glutamatergic NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Dendritic Spine Development Neuron Projection Glutamate Receptor Signaling Pathway Regulation Of Nervous System Process Protein Autophosphorylation Synapse Developmental Process Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Neuromuscular Junction Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Binding Chemical Synaptic Transmission Ionotropic Glutamate Receptor Binding Modulation Of Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Trans-synaptic Signaling AMPA Glutamate Receptor Clustering Protein Phosphorylation Kinase Binding Synaptic Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Postsynaptic Membrane Phosphorylation Synaptic Transmission, Glutamatergic Neuron Spine Protein Modification Process Receptor Clustering Neuron Projection Morphogenesis Long-term Synaptic Potentiation Signaling Regulation Of Membrane Potential Social Behavior Glycine Binding
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