OSTF1 and HES7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OSTF1	HES7
Description		osteoclast stimulating factor 1	hes family bHLH transcription factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Chromatin Nucleus
	Molecular Function	Protein Binding SH3 Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Ossification Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Anterior/posterior Pattern Specification Post-anal Tail Morphogenesis Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis
Pathways		Neutrophil degranulation	Somitogenesis
Drugs
Diseases			Spondylocostal dysostosis (SCD)
GWAS		Allergic rhinitis ( 25085501) Glucose homeostasis traits ( 25524916) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Resting-state electroencephalogram vigilance ( 29703947) Systemic sclerosis ( 30247649) Urinary magnesium-to-creatinine ratio ( 29093028)	Height ( 25282103)
Interacting Genes		51 interacting genes: AGR2 APP BORCS6 CBL CBLB CCDC33 CRX CTDSP1 CUEDC1 DPPA4 DTX3 EFS ERRFI1 FASLG FBXO7 GAPDH GGN HES7 HTT KHDRBS1 KLHL42 LATS1 LMNA MAPK6 MED19 MEOX2 NFYC NUTM1 NUTM2F PBX4 PICK1 PRRG4 REL SDCBP SF1 SF3A2 SMN1 SNW1 SOCS7 SYNGAP1 TRIB3 TRIM54 VPS37B WASF1 WASHC1 WASL YPEL3 ZBTB42 ZBTB7B ZNF655 ZNF688	6 interacting genes: OSTF1 PIH1D2 PRPF31 QARS1 TCEA2 TCEANC
Entrez ID		26578	84667
HPRD ID		17808	09729
Ensembl ID		ENSG00000134996	ENSG00000179111
Uniprot IDs		Q92882	Q9BYE0
PDB IDs		1X2K 1ZLM 3EHQ 3EHR
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor-mediated Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway SH3 Domain Binding Regulation Of ERBB Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Synapse Structure Or Activity Regulation Of Receptor Internalization Nucleus Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway MRNA 3'-splice Site Recognition Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Transcription By RNA Polymerase II Establishment Of Organelle Localization Regulation Of Actin Nucleation Neuron Projection Organization Cytoskeleton-dependent Intracellular Transport Regulation Of Endocytosis Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Localization Spliceosomal Complex Assembly Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Arp2/3 Complex Binding Regulation Of Supramolecular Fiber Organization Regulation Of Metabolic Process Regulation Of Plasma Membrane Organization Negative Regulation Of Alpha-beta T Cell Proliferation Localization Within Membrane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endocytosis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway	RNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Localization Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation U4atac SnRNP SnRNP Binding U4atac SnRNA Binding SnoRNA Localization Protein-RNA Complex Assembly Spliceosomal Tri-snRNP Complex R2TP Complex U4 SnRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade U4 SnRNP Box C/D SnoRNP Assembly Spliceosomal Tri-snRNP Complex Assembly Precatalytic Spliceosome Ribonucleoprotein Complex Transcription Elongation Factor Complex
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