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CHIC2 and KDR
CHIC2
KDR
Description
cysteine rich hydrophobic domain 2
kinase insert domain receptor
Image
GO Annotations
Cellular Component
Golgi Apparatus
Golgi-associated Vesicle
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Extracellular Region
Nucleus
Cytoplasm
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Cytoplasmic Vesicle
Receptor Complex
Membrane Raft
Anchoring Junction
Cell Periphery
Sorting Endosome
Molecular Function
Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Transferase Activity
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
Biological Process
Angiogenesis
Ovarian Follicle Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Lymph Vessel Development
Positive Regulation Of Mesenchymal Cell Proliferation
Epithelial Cell Maturation
Endocardium Development
Endothelium Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Mesenchymal Cell Proliferation
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Cell Differentiation
Lung Development
Positive Regulation Of Cell Migration
Positive Regulation Of BMP Signaling Pathway
Embryonic Hemopoiesis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Surfactant Homeostasis
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Fate Commitment
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Lung Alveolus Development
Post-embryonic Camera-type Eye Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Mitochondrial Depolarization
Calcium Ion Homeostasis
Epithelial Tube Morphogenesis
Blood Vessel Endothelial Cell Differentiation
Vascular Wound Healing
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Stem Cell Proliferation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Bone Development
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Endothelial Cell Chemotaxis
Positive Regulation Of Vasculogenesis
Pathways
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Sorafenib
Sunitinib
1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
Pegdinetanib
RAF-265
Linifanib
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Tivozanib
Fostamatinib
Erdafitinib
Foretinib
Ripretinib
Pralsetinib
Olinvacimab
Diseases
GWAS
Blood pressure (
21909110
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Metabolite levels (
23823483
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulse pressure (
28739976
30487518
)
Serum metabolite levels (CMS) (
31636271
)
Subcortical volume (MOSTest) (
32665545
)
Blood protein levels (
30072576
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
68 interacting genes:
ADAMTSL4
AGXT
AXIN2
C1QTNF2
CARD10
CATSPER1
CBY2
CDR2
CEP44
CYSRT1
DNAL4
FBLN1
GMCL1
HOXA1
ITSN2
KANK2
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP2-3
KRTAP2-4
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP6-2
LCE1A
LCE1B
LCE1C
LCE1D
LCE1F
LCE2C
LCE3A
LCE3C
LCE3D
LCE3E
LCE5A
LCN2
LZTS2
MDFI
MEOX2
MTUS2
MYF5
MYPOP
NBPF19
NDUFB7
NOTCH2NLA
OTX1
PLEKHF1
PLEKHF2
PLEKHG4
PNMA1
POU4F2
PPARA
REL
SCNM1
SDCBP
TCF4
TOP3B
TUBGCP4
U2AF2
ZNF330
ZNF837
63 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
KPNA4
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SNCA
SRC
STAT1
STYX
SYNGAP1
TIMP3
USP7
VEGFA
VEGFC
VEGFD
YES1
Entrez ID
26511
3791
HPRD ID
10373
01867
Ensembl ID
ENSG00000109220
ENSG00000128052
Uniprot IDs
Q9UKJ5
P35968
PDB IDs
8SUV
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
6XVJ
6XVK
Enriched GO Terms of Interacting Partners
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Intermediate Filament
Keratin Filament
Keratinization
Epidermis Development
Tissue Development
Identical Protein Binding
Regulation Of Transformation Of Host Cell By Virus
Protein Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Anatomical Structure Formation Involved In Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Ephrin Receptor Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Angiogenesis
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of MAPK Cascade
Regulation Of Angiogenesis
Cytoplasm
Regulation Of Vasculature Development
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor 2 Binding
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Regulation Of Programmed Cell Death
Response To Platelet-derived Growth Factor
T Cell Costimulation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Cell Motility
SH3 Domain Binding
Developmental Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Cytosol
Ephrin Receptor Signaling Pathway
Focal Adhesion
Immune Response-activating Signaling Pathway
Protein Dephosphorylation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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