ADCY2 and NUF2

		ADCY2	NUF2
Description		adenylate cyclase 2	NUF2 component of NDC80 kinetochore complex
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite Membrane Raft	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane Ndc80 Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Manganese Ion Binding Metal Ion Binding	Protein Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Cellular Response To Forskolin	Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Meiotic Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 31043756 34002096 24618891) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Asthma ( 29273806) Bipolar disorder ( 34002096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Diffusing capacity of carbon monoxide ( 30694715) Height ( 28552196) Myopia ( 27182965)
Interacting Genes		6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2	11 interacting genes: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 OGT SDCBP2
Entrez ID		108	83540
HPRD ID		00052	10817
Ensembl ID		ENSG00000078295	ENSG00000143228
Uniprot IDs		Q08462 Q71UM8	Q9BZD4
PDB IDs			2VE7 3IZ0 8G0P
Enriched GO Terms of Interacting Partners?		G Protein-coupled Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Protein Transport G Protein-coupled Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid CAMP Biosynthetic Process Adenylate Cyclase Activity Response To Alcohol Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Cellular Response To Forskolin Regulation Of Secretion By Cell Response To Forskolin Regulation Of Secretion Cellular Response To Catecholamine Stimulus Phosphorus-oxygen Lyase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G-protein Beta-subunit Binding CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Response To Lipid Heterotrimeric G-protein Complex Regulation Of Biological Quality Nervous System Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Protein Localization System Process Purine-containing Compound Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glutaryl-CoA Dehydrogenase Activity Positive Regulation Of Interleukin-1 Beta Production Nucleoside Phosphate Biosynthetic Process Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Negative Regulation Of Protein Secretion Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Eosinophil Degranulation	Mitotic Spindle Organization Membraneless Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Kinetochore Kinetochore Organization Organelle Assembly Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Midzone Attachment Of Spindle Microtubules To Kinetochore Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis I Chromosome, Centromeric Region Kinetochore Binding Chromosome Passenger Complex Midbody Cell Cycle G2/M Phase Transition Microtubule Cytoskeleton Organization Microtubule-based Process Mitotic Spindle Midzone Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Spindle Assembly Involved In Female Meiosis Kinetochore Assembly Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly Regulation Of Sister Chromatid Segregation Condensed Chromosome, Centromeric Region Positive Regulation Of Cell Cycle Checkpoint Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Meiotic Spindle Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Segregation Regulation Of Nuclear Division Protein Serine/threonine/tyrosine Kinase Activity Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Division Organelle Localization Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Spindle Microtubule Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle
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