ADCY2 and ADCY1

Number of citations of the paper that reports this interaction (PubMedID 8692867)
9

Data Source:
HPRD (in vitro)

		ADCY2	ADCY1
Description		adenylate cyclase 2	adenylate cyclase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite Membrane Raft	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Membrane Raft Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Manganese Ion Binding Metal Ion Binding	Nucleotide Binding Adenylate Cyclase Activity Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Cellular Response To Forskolin	CAMP Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Long-term Memory Cyclic Nucleotide Biosynthetic Process Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Regulation Of Circadian Rhythm Rhythmic Process Modulation Of Chemical Synaptic Transmission Cellular Response To Calcium Ion Presynaptic Modulation Of Chemical Synaptic Transmission Neuroinflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose	Adenosine phosphate ATP Hyoscyamine Colforsin Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 31043756 34002096 24618891) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Night sleep phenotypes ( 27126917) Subjective response to lithium treatment in bipolar disorder ( 26503763)
Interacting Genes		6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2	4 interacting genes: ADCY2 FZD7 GNAI2 SERTAD1
Entrez ID		108	107
HPRD ID		00052	00053
Ensembl ID		ENSG00000078295	ENSG00000164742
Uniprot IDs		Q08462 Q71UM8	C9J1J0 Q08828
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Protein Transport G Protein-coupled Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid CAMP Biosynthetic Process Adenylate Cyclase Activity Response To Alcohol Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Cellular Response To Forskolin Regulation Of Secretion By Cell Response To Forskolin Regulation Of Secretion Cellular Response To Catecholamine Stimulus Phosphorus-oxygen Lyase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G-protein Beta-subunit Binding CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Response To Lipid Heterotrimeric G-protein Complex Regulation Of Biological Quality Nervous System Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Protein Localization System Process Purine-containing Compound Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glutaryl-CoA Dehydrogenase Activity Positive Regulation Of Interleukin-1 Beta Production Nucleoside Phosphate Biosynthetic Process Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Negative Regulation Of Protein Secretion Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Eosinophil Degranulation	Phosphorus-oxygen Lyase Activity Dendrite Response To Forskolin Adenylate Cyclase Binding CAMP Biosynthetic Process Cellular Response To Forskolin Adenylate Cyclase Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Lipid G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Purinergic Nucleotide Receptor Signaling Pathway Guanyl Nucleotide Binding Regulation Of Urine Volume Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Positive Regulation Of MAPK Cascade Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Superoxide Anion Generation Regulation Of Cell Population Proliferation Neuronal Dense Core Vesicle Cell Division G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Somatic Stem Cell Division Negative Regulation Of Cell Fate Commitment Wnt Receptor Activity Regulation Of Cardiac Muscle Cell Differentiation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Negative Regulation Of Ectodermal Cell Fate Specification Regulation Of Phosphorylation Negative Regulation Of Cardiocyte Differentiation Mesenchymal To Epithelial Transition Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Negative Regulation Of Cardiac Muscle Cell Differentiation Sarcoplasm CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Stem Cell Division Regulation Of Cell Fate Specification Gamma-aminobutyric Acid Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Wnt-protein Binding
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