ADCY2

Description		adenylate cyclase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Dendrite Membrane Raft
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Lyase Activity Phosphorus-oxygen Lyase Activity Manganese Ion Binding Metal Ion Binding
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 31043756 34002096 24618891) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)
Novel Interacting Genes		8 novel interacting genes: AHRR CDH18 GCDH ISL1 NUF2 OBP2A RDH12 SLC9A3
Interacting Genes		6 interacting genes: ADCY1 ADCY5 DRD4 F2RL1 GNAS GNG2
Entrez ID		108
HPRD ID		00052
Ensembl ID		ENSG00000078295
Uniprot IDs		Q08462 Q71UM8
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Secretion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Protein Transport G Protein-coupled Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid CAMP Biosynthetic Process Adenylate Cyclase Activity Response To Alcohol Regulation Of Hormone Secretion Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Cellular Response To Forskolin Regulation Of Secretion By Cell Response To Forskolin Regulation Of Secretion Cellular Response To Catecholamine Stimulus Phosphorus-oxygen Lyase Activity Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G-protein Beta-subunit Binding CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Response To Lipid Heterotrimeric G-protein Complex Regulation Of Biological Quality Nervous System Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Protein Localization System Process Purine-containing Compound Biosynthetic Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glutaryl-CoA Dehydrogenase Activity Positive Regulation Of Interleukin-1 Beta Production Nucleoside Phosphate Biosynthetic Process Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Negative Regulation Of Protein Secretion Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Eosinophil Degranulation
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