GBP3 and MAP4K4

Number of citations of the paper that reports this interaction (PMID 12387898)
1

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GBP3	MAP4K4
Gene Name		guanylate binding protein 3	mitogen-activated protein kinase kinase kinase kinase 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Metabolic Process Defense Response To Virus	Protein Phosphorylation Signal Transduction By Phosphorylation Microvillus Assembly Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Catalytic Activity
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		1 interactors: MAP4K4	18 interactors: BRCA1 CASP8 DOK1 GBP3 HIST2H2BE ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2
Entrez ID		2635	9448
HPRD ID		02683	05235
Ensembl ID		ENSG00000117226	ENSG00000071054
Uniprot IDs		Q9H0R5	B7Z3V5 O95819
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Hormone Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Protein Secretion Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Negative Regulation Of Secretion By Cell Regulation Of JNK Cascade Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Neuron Differentiation Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Signal Transduction By Phosphorylation Negative Regulation Of Neurogenesis Negative Regulation Of Cell Development	Response To External Stimulus Regulation Of Cell Adhesion Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Developmental Process Signaling Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Response To Stimulus Cellular Response To Organic Substance Anatomical Structure Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Death Regulation Of Apoptotic Process System Development Positive Regulation Of Cell Adhesion Regulation Of Cell Death Signal Transduction Response To Abiotic Stimulus Response To Other Organism Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cell Projection Organization Response To Biotic Stimulus Nervous System Development Cellular Response To Mechanical Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Defense Response Response To Organic Substance Axonogenesis Regulation Of Organelle Organization Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Cell Death Axon Development Negative Regulation Of Necrotic Cell Death Response To Stress Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Necroptotic Process Movement Of Cell Or Subcellular Component
Tagcloud ?			abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis
Tagcloud (Difference) ?			abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis
Tagcloud (Intersection) ?