CRIP2 and NOTCH3

Number of citations of the paper that reports this interaction (PubMedID 25356737)
22

Data Source:
BioGRID (pull down)

		CRIP2	NOTCH3
Description		cysteine rich protein 2	notch receptor 3
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GO Annotations	Cellular Component	Cell Cortex	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Hemopoiesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Notch Signaling Pathway Axon Guidance Neuroblast Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Regulation Of Developmental Process Glomerular Capillary Formation Positive Regulation Of MiRNA Transcription
Pathways			Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases			Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS			Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)
Interacting Genes		19 interacting genes: APP ATN1 ATP1B1 ATXN1 CDC42 ERBB2 GADD45G GATA4 GATA6 KLF10 NOTCH3 OSGEP PCYT2 PRKG1 PTPN13 SMN1 SPRY2 SRF TK1	53 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		1397	4854
HPRD ID		03113	02607
Ensembl ID		ENSG00000182809	ENSG00000074181
Uniprot IDs		P52943	Q9UM47
PDB IDs		2CU8	4ZLP 5CZV 5CZX 6WQU 6XSW 8OS0
Enriched GO Terms of Interacting Partners?		Developmental Growth Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Neuron Projection Development Regulation Of Multicellular Organismal Process Developmental Cell Growth Cardiac Vascular Smooth Muscle Cell Differentiation Developmental Growth Involved In Morphogenesis Tube Morphogenesis NFAT Protein Binding Atrioventricular Node Development Cardiocyte Differentiation Muscle Tissue Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cell Fate Commitment Vascular Associated Smooth Muscle Cell Differentiation Cardiac Muscle Tissue Development Negative Regulation Of Transcription By RNA Polymerase II Atrioventricular Canal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Multicellular Organismal Development Intestinal Epithelial Cell Differentiation Forebrain Development System Development Wound Healing Regulation Of MiRNA Transcription Regulation Of Developmental Process Developmental Process System Process Protein Kinase Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Muscle System Process Positive Regulation Of Growth Collateral Sprouting Associative Learning Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Notch Binding Tissue Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Notch Signaling Pathway Regulation Of Development, Heterochronic MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Tube Morphogenesis Positive Regulation Of Developmental Process Endothelial Cell Fate Specification Morphogenesis Of An Epithelium Cell Surface Receptor Signaling Pathway Loop Of Henle Development Calcium Ion Binding Neuron Differentiation Myoblast Differentiation Negative Regulation Of Viral Life Cycle Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Inhibition Of Neuroepithelial Cell Differentiation Gamma-secretase Complex Positive Regulation Of Signal Transduction Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Lymphocyte Migration Into Lymphoid Organs Notch Receptor Processing Transcription Coactivator Activity Negative Regulation Of Notch Signaling Pathway Epithelial Tube Morphogenesis Positive Regulation Of Kidney Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Amyloid-beta Formation Somitogenesis Anatomical Structure Morphogenesis Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Stem Cell Population Maintenance Endothelial Tube Morphogenesis Segmentation Maintenance Of Cell Number Positive Regulation Of Cellular Component Organization Nephron Development Inner Ear Development
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