CRIP2 and PTPN13

Number of citations of the paper that reports this interaction (PubMedID 12839623)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CRIP2	PTPN13
Description		cysteine rich protein 2	protein tyrosine phosphatase non-receptor type 13
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GO Annotations	Cellular Component	Cell Cortex	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Cell Projection Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Hemopoiesis	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Toxic Substance Negative Regulation Of Excitatory Synapse Assembly
Pathways			Synthesis of PIPs at the plasma membrane Interleukin-37 signaling RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Tinnitus ( 33742053) Word spelling ( 30741946)
Interacting Genes		19 interacting genes: APP ATN1 ATP1B1 ATXN1 CDC42 ERBB2 GADD45G GATA4 GATA6 KLF10 NOTCH3 OSGEP PCYT2 PRKG1 PTPN13 SMN1 SPRY2 SRF TK1	26 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 DSCAM EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 VANGL2 YWHAZ
Entrez ID		1397	5783
HPRD ID		03113	02602
Ensembl ID		ENSG00000182809	ENSG00000163629
Uniprot IDs		P52943	Q12923
PDB IDs		2CU8	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ 7QCX 7QCY 7XTY
Enriched GO Terms of Interacting Partners?		Developmental Growth Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Neuron Projection Development Regulation Of Multicellular Organismal Process Developmental Cell Growth Cardiac Vascular Smooth Muscle Cell Differentiation Developmental Growth Involved In Morphogenesis Tube Morphogenesis NFAT Protein Binding Atrioventricular Node Development Cardiocyte Differentiation Muscle Tissue Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cell Fate Commitment Vascular Associated Smooth Muscle Cell Differentiation Cardiac Muscle Tissue Development Negative Regulation Of Transcription By RNA Polymerase II Atrioventricular Canal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Multicellular Organismal Development Intestinal Epithelial Cell Differentiation Forebrain Development System Development Wound Healing Regulation Of MiRNA Transcription Regulation Of Developmental Process Developmental Process System Process Protein Kinase Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Muscle System Process Positive Regulation Of Growth Collateral Sprouting Associative Learning Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Protein Phosphatase Binding Glutamatergic Synapse Neuron Projection Guidance Axon Guidance Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction CD95 Death-inducing Signaling Complex Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cell Junction Assembly Positive Regulation Of Cell Population Proliferation Tube Formation Death-inducing Signaling Complex Cell Junction Organization Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Regulation Of Intracellular Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Population Proliferation Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Cellular Developmental Process Cell-cell Junction Organization Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Beta-catenin Destruction Complex Positive Regulation Of Apoptotic Process Lateral Plasma Membrane Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Rho Protein Signal Transduction Wnt Signalosome Adherens Junction Nervous System Development Lamellipodium
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