KLHL3 and ACSL6

		KLHL3	ACSL6
Description		kelch like family member 3	acyl-CoA synthetase long chain family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Gene Expression Macroautophagy Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Monoatomic Ion Homeostasis Potassium Ion Homeostasis Renal Absorption Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neuroblast Proliferation Long-chain Fatty-acyl-CoA Biosynthetic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		16 interacting genes: AKT1 CFAP206 GNAI1 GNAO1 KLHL12 MORF4L2 OPRD1 PPP3CA PRKACA RBX1 SYNCRIP SYT2 TNPO2 UBE2D3 WNK3 WNK4	3 interacting genes: PCMTD2 PHYH ZNF655
Entrez ID		26249	23305
HPRD ID		09011	09190
Ensembl ID		ENSG00000146021	ENSG00000164398
Uniprot IDs		Q9UH77	A0A494BZW8 A0A494C0B6 A0A494C0J9 A0A499FJL5 B2RB13 B4DFW3 C9J8C7 Q9UKU0
PDB IDs		4CH9 4HXI 5NKP
Enriched GO Terms of Interacting Partners?		Renal Sodium Ion Transport Renal Sodium Ion Absorption Renal Absorption Renal System Process Regulation Of Metal Ion Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Negative Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Proteasomal Protein Catabolic Process Regulation Of Transport Positive Regulation Of Steroid Biosynthetic Process Adenylate Cyclase Regulator Activity Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Pancreatic Juice Secretion Ubiquitin-dependent Protein Catabolic Process Regulation Of System Process Modification-dependent Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization Regulation Of Cholesterol Metabolic Process Protein Catabolic Process Negative Regulation Of Secretion Protein Monoubiquitination Sodium Ion Transport Proteolysis Involved In Protein Catabolic Process TORC1 Signaling Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling Regulation Of Sodium Ion Transport Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Calcium Ion Transport Regulation Of Steroid Biosynthetic Process Protein Modification Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Nuclear Transport Nucleocytoplasmic Transport Vascular Endothelial Cell Response To Fluid Shear Stress Nucleotide Binding	Glycine Amidinotransferase Activity Amidinotransferase Activity Homogentisate 1,2-dioxygenase Activity 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity
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