ACSL6 and PCMTD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACSL6	PCMTD2
Description		acyl-CoA synthetase long chain family member 6	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cytoplasm
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Protein Homodimerization Activity Arachidonate-CoA Ligase Activity	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Neuroblast Proliferation Long-chain Fatty-acyl-CoA Biosynthetic Process
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Inflammatory bowel disease ( 23128233 28067908) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Apolipoprotein B levels ( 32203549) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Clozapine-induced cytotoxicity ( 25656473) Coffee consumption ( 31046077) Estimated glomerular filtration rate ( 31152163) LDL cholesterol levels ( 32203549)
Interacting Genes		3 interacting genes: PCMTD2 PHYH ZNF655	5 interacting genes: ACSL6 ATP13A2 PIGP TRIP13 VAC14
Entrez ID		23305	55251
HPRD ID		09190	12764
Ensembl ID		ENSG00000164398	ENSG00000203880
Uniprot IDs		A0A494BZW8 A0A494C0B6 A0A494C0J9 A0A499FJL5 B2RB13 B4DFW3 C9J8C7 Q9UKU0	Q9NV79
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycine Amidinotransferase Activity Amidinotransferase Activity Homogentisate 1,2-dioxygenase Activity 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity	Lipid Biosynthetic Process Organophosphate Biosynthetic Process Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity PAS Complex Phosphatidylinositol Biosynthetic Process Meiotic Recombination Checkpoint Signaling Organophosphate Metabolic Process Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Late Endosome Membrane Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Cupric Ion Binding Glycerophospholipid Biosynthetic Process Phospholipid Biosynthetic Process Phosphatidylinositol N-acetylglucosaminyltransferase Activity Phosphatidylinositol Metabolic Process Female Meiosis I Meiotic Cell Cycle Checkpoint Signaling Lipid Metabolic Process Regulation Of Chaperone-mediated Autophagy Polyamine Transmembrane Transport Glycerophospholipid Metabolic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Presynaptic Endosome Negative Regulation Of Meiotic Nuclear Division Cellular Response To Manganese Ion Arachidonate-CoA Ligase Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process ATP Hydrolysis Activity Long-chain Fatty Acid-CoA Ligase Activity Phosphate-containing Compound Metabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion ATP Binding Negative Regulation Of Meiotic Cell Cycle Female Meiotic Nuclear Division Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Exosomal Secretion Synaptonemal Complex Assembly Endoplasmic Reticulum
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