CYSRT1 and PKD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYSRT1	PKD2
Description		cysteine rich tail 1	polycystin 2, transient receptor potential cation channel
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Exosome	Polycystin Complex Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Basolateral Plasma Membrane Lamellipodium Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Motile Cilium Vesicle Monoatomic Ion Channel Complex Cation Channel Complex Ciliary Basal Body Cell Projection Basal Cortex Ciliary Membrane Extracellular Exosome Mitotic Spindle Non-motile Cilium Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Migrasome
	Molecular Function	Protein Binding Identical Protein Binding	Signaling Receptor Binding Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Channel Activity Outward Rectifier Potassium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Transmembrane Transporter Binding Metal Ion Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding Transcription Regulator Inhibitor Activity
	Biological Process	Biological Process Involved In Interaction With Symbiont Establishment Of Skin Barrier	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Spinal Cord Development Neural Tube Development Monoatomic Ion Transmembrane Transport Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Chordate Embryonic Development Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Establishment Of Localization In Cell Regulation Of Cell Cycle Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS			Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)
Interacting Genes		503 interacting genes: A1CF ACTMAP ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 AGXT ALDH3B1 ALPP ANAPC11 ANKS1A AQP1 AREG ARHGAP33 ARHGAP9 ARID5A ASTL ATG9A ATOSB ATPAF2 ATXN7L2 AVPI1 B4GALT7 BAG3 BAG6 BAHD1 BAIAP2L1 BEX1 BEX2 BLCAP BMP7 BRME1 BSCL2 C11orf16 C11orf87 C22orf39 CACNA1A CACNA1S CARD10 CARHSP1 CATSPER1 CBLL2 CBX2 CCDC120 CCDC187 CCDC28A-AS1 CCER1 CCNK CD300LG CDKL3 CELF5 CERCAM CERK CES1 CFAP206 CFP CHCHD2 CHCHD3 CHIC2 CHRD CHRNG CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COL8A1 COMP CRCT1 CREB5 CRH CRY2 CRYBA1 CRYBA2 CSF1 CST2 CST9L CTRC CTSG CTSZ CXCL16 CYP21A2 CYP2S1 DACT2 DALRD3 DBF4B DBH DCDC2B DDX43 DLGAP2 DMRT3 DNAJA3 DNASE1L3 DOCK2 DRC4 DVL3 ECE1 ECM1 EEIG1 EFEMP1 EFEMP2 EMC7 ENKD1 EPS8L1 ERH ESR2 ETNK2 FADS6 FAM124B FAM221A FAM221B FAM83A FAM90A1 FARS2 FASLG FBXL9P FBXW5 FEZF1 FHL3 FOXD2 FOXD4L1 FOXD4L3 FOXH1 FRS3 FRZB FZD10 GARIN6 GATA2 GATA3 GATA5 GCSAM GEM GGN GLB1L2 GLP1R GLYAT GNE GNG13 GPANK1 GPATCH2L GPRIN2 GPS2 GRN GSTP1 GUCD1 HBZ HCK HDHD3 HEY2 HHEX HLX HOXA1 HOXB5 HOXB9 HOXC8 HOXC9 HR HRG HSBP1 HSD3B7 HSPA12B HSPD1 HYAL2 HYPK ICAM1 ICAM4 IL16 INCA1 INO80B INPP5D INS INTS5 IQCN IQUB ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT20 KRT31 KRT33B KRT34 KRT81 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-3 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 KRTAP9-2 KRTAP9-3 KRTAP9-8 KSR2 LAGE3 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LENG8 LGALS9C LMF2 LMNTD2 LMO3 LMO4 LNX1 LONRF1 LONRF3 LRFN4 LRRC41 LRRN4 LYVE1 MACROH2A1 MAPKBP1 MCRS1 MED25 MELTF MEOX2 MGAT5B MIIP MKRN3 MRPL23 MRPL40 MSRB1 MT1M MTA1 MTNR1A MXD3 MXI1 MYPOP NBPF19 NDUFA9 NDUFAF3 NECTIN2 NECTIN3 NEU2 NEU4 NKD1 NMU NOTCH2NLA NOXA1 NPBWR2 NPDC1 NPPB NR1D2 NR4A3 NSD1 NTAQ1 NTN4 NUBP2 NUFIP2 OLIG3 OR7A17 OTOS OTX1 P2RX7 PATZ1 PCSK5 PDE9A PGAP2 PGAP6 PHETA1 PHLDA1 PITX1 PITX2 PKD2 PKN1 PLA2G10 PLAC8 PLEKHN1 PLLP POU4F2 PPP1CB PPY PRF1 PRKAA2 PRKAB2 PROC PROP1 PRPF31 PRR19 PRR22 PRR30 PRR34 PRR35 PTGDS PTK7 PTPMT1 PVR QRICH1 R3HDM2 RAB3IL1 RALGDS RAMAC RAMP3 RASD1 RBM22 RBP3 RECK REM2 RGL2 RGS3 RHBG RHNO1 RNF38 RPS19BP1 RPUSD3 RSPO2 RTN4RL1 SAPCD2 SAXO1 SAXO4 SAXO5 SCARF1 SCNM1 SEMA3B SEMA4C SH3KBP1 SH3RF2 SHFL SHISA6 SLC12A4 SLC13A5 SLC23A1 SLC25A18 SLC25A48 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SLIT1 SMARCC1 SMARCD1 SMARCE1 SMCP SMOC1 SMUG1 SNRPB SNRPC SNX18 SOCS7 SPATA24 SPATA3 SPATA46 SPATA8 SPEF1 SPG7 SPMIP2 SPMIP4 SPMIP6 SPMIP9 SPON1 SPPL2C SPRY1 SPTSSA SRD5A2 SSC4D STK16 TAPBPL TBX2 TBX6 TCAF1 TCEA2 TCEANC TCF7L2 TENT5B TEPSIN TFAP2D TGFB1 THAP7 TIMM22 TLE5 TM7SF2 TMEM174 TNIP1 TNIP3 TNK2 TNS4 TRAPPC14 TREX1 TRIM42 TSGA10IP TSPAN4 TTC23 TTPA TYK2 UBXN7 USP54 UTP23 VASN VENTX VGLL3 VSTM4 VWC2 VWC2L WDR25 WIF1 WNT11 WT1 YPEL3 YY1 ZBTB25 ZBTB4 ZCCHC14 ZDHHC1 ZFHX2 ZIC1 ZMYND10 ZNF124 ZNF266 ZNF319 ZNF330 ZNF34 ZNF408 ZNF414 ZNF417 ZNF419 ZNF438 ZNF439 ZNF440 ZNF441 ZNF446 ZNF497 ZNF552 ZNF575 ZNF580 ZNF581 ZNF587 ZNF648 ZNF669 ZNF683 ZNF696 ZNF764 ZNF775 ZNF786 ZNF835 ZNF837 ZNF843 ZNHIT1 ZSCAN5A	21 interacting genes: ACTN2 CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1
Entrez ID		375791	5311
HPRD ID		14696	01437
Ensembl ID		ENSG00000197191	ENSG00000118762
Uniprot IDs		A8MQ03	Q13563 Q9UEU6
PDB IDs			2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8 8HK7 8K3S 9DLI 9DWQ
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Animal Organ Morphogenesis DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Structural Constituent Of Skin Epidermis	Transmembrane Transporter Binding Intermediate Filament Actin Filament Sarcomere Alcohol Dehydrogenase (NAD+) Activity Actin Filament Binding Striated Muscle Cell Development Regulation Of Cytoskeleton Organization Actin Binding Cytosol All-trans-retinol Dehydrogenase (NAD+) Activity Cation Channel Complex Actin-myosin Filament Sliding Muscle Filament Sliding Protein Domain Specific Binding Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Keratin Filament Muscle Cell Development Structural Constituent Of Cytoskeleton Regulation Of Muscle System Process Positive Regulation Of Cation Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Retinoic Acid Metabolic Process Protein Heterooligomerization Actin Cytoskeleton Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Actin Filament Uncapping Identical Protein Binding Butanol Dehydrogenase (NAD+) Activity Ethanol Dehydrogenase (NAD+) Activity Actin Filament Polymerization Regulation Of Calcium Ion Transmembrane Transport Regulation Of System Process S-methyl-5-thioadenosine Phosphorylase Activity Metanephric Distal Tubule Morphogenesis Monoatomic Cation Channel Activity Regulation Of ATP-dependent Activity Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Heart Rate By Epinephrine Actin-mediated Cell Contraction
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