CYSRT1 and BAG3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYSRT1	BAG3
Description		cysteine rich tail 1	BAG cochaperone 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Exosome	Stress Fiber Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Aggresome Z Disc Ciliary Basal Body Protein Folding Chaperone Complex
	Molecular Function	Protein Binding Identical Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Protein-folding Chaperone Binding Protein Carrier Chaperone
	Biological Process	Biological Process Involved In Interaction With Symbiont Establishment Of Skin Barrier	Autophagosome Assembly Protein Folding Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Striated Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Transport Along Microtubule Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy
Pathways			Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 27841878) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic dilated cardiomyopathy ( 21459883) Left ventricular ejection fraction ( 32605384 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Parkinson's disease ( 28892059 27182965 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		503 interacting genes: A1CF ACTMAP ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 AGXT ALDH3B1 ALPP ANAPC11 ANKS1A AQP1 AREG ARHGAP33 ARHGAP9 ARID5A ASTL ATG9A ATOSB ATPAF2 ATXN7L2 AVPI1 B4GALT7 BAG3 BAG6 BAHD1 BAIAP2L1 BEX1 BEX2 BLCAP BMP7 BRME1 BSCL2 C11orf16 C11orf87 C22orf39 CACNA1A CACNA1S CARD10 CARHSP1 CATSPER1 CBLL2 CBX2 CCDC120 CCDC187 CCDC28A-AS1 CCER1 CCNK CD300LG CDKL3 CELF5 CERCAM CERK CES1 CFAP206 CFP CHCHD2 CHCHD3 CHIC2 CHRD CHRNG CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COL8A1 COMP CRCT1 CREB5 CRH CRY2 CRYBA1 CRYBA2 CSF1 CST2 CST9L CTRC CTSG CTSZ CXCL16 CYP21A2 CYP2S1 DACT2 DALRD3 DBF4B DBH DCDC2B DDX43 DLGAP2 DMRT3 DNAJA3 DNASE1L3 DOCK2 DRC4 DVL3 ECE1 ECM1 EEIG1 EFEMP1 EFEMP2 EMC7 ENKD1 EPS8L1 ERH ESR2 ETNK2 FADS6 FAM124B FAM221A FAM221B FAM83A FAM90A1 FARS2 FASLG FBXL9P FBXW5 FEZF1 FHL3 FOXD2 FOXD4L1 FOXD4L3 FOXH1 FRS3 FRZB FZD10 GARIN6 GATA2 GATA3 GATA5 GCSAM GEM GGN GLB1L2 GLP1R GLYAT GNE GNG13 GPANK1 GPATCH2L GPRIN2 GPS2 GRN GSTP1 GUCD1 HBZ HCK HDHD3 HEY2 HHEX HLX HOXA1 HOXB5 HOXB9 HOXC8 HOXC9 HR HRG HSBP1 HSD3B7 HSPA12B HSPD1 HYAL2 HYPK ICAM1 ICAM4 IL16 INCA1 INO80B INPP5D INS INTS5 IQCN IQUB ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT20 KRT31 KRT33B KRT34 KRT81 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-3 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 KRTAP9-2 KRTAP9-3 KRTAP9-8 KSR2 LAGE3 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LENG8 LGALS9C LMF2 LMNTD2 LMO3 LMO4 LNX1 LONRF1 LONRF3 LRFN4 LRRC41 LRRN4 LYVE1 MACROH2A1 MAPKBP1 MCRS1 MED25 MELTF MEOX2 MGAT5B MIIP MKRN3 MRPL23 MRPL40 MSRB1 MT1M MTA1 MTNR1A MXD3 MXI1 MYPOP NBPF19 NDUFA9 NDUFAF3 NECTIN2 NECTIN3 NEU2 NEU4 NKD1 NMU NOTCH2NLA NOXA1 NPBWR2 NPDC1 NPPB NR1D2 NR4A3 NSD1 NTAQ1 NTN4 NUBP2 NUFIP2 OLIG3 OR7A17 OTOS OTX1 P2RX7 PATZ1 PCSK5 PDE9A PGAP2 PGAP6 PHETA1 PHLDA1 PITX1 PITX2 PKD2 PKN1 PLA2G10 PLAC8 PLEKHN1 PLLP POU4F2 PPP1CB PPY PRF1 PRKAA2 PRKAB2 PROC PROP1 PRPF31 PRR19 PRR22 PRR30 PRR34 PRR35 PTGDS PTK7 PTPMT1 PVR QRICH1 R3HDM2 RAB3IL1 RALGDS RAMAC RAMP3 RASD1 RBM22 RBP3 RECK REM2 RGL2 RGS3 RHBG RHNO1 RNF38 RPS19BP1 RPUSD3 RSPO2 RTN4RL1 SAPCD2 SAXO1 SAXO4 SAXO5 SCARF1 SCNM1 SEMA3B SEMA4C SH3KBP1 SH3RF2 SHFL SHISA6 SLC12A4 SLC13A5 SLC23A1 SLC25A18 SLC25A48 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SLIT1 SMARCC1 SMARCD1 SMARCE1 SMCP SMOC1 SMUG1 SNRPB SNRPC SNX18 SOCS7 SPATA24 SPATA3 SPATA46 SPATA8 SPEF1 SPG7 SPMIP2 SPMIP4 SPMIP6 SPMIP9 SPON1 SPPL2C SPRY1 SPTSSA SRD5A2 SSC4D STK16 TAPBPL TBX2 TBX6 TCAF1 TCEA2 TCEANC TCF7L2 TENT5B TEPSIN TFAP2D TGFB1 THAP7 TIMM22 TLE5 TM7SF2 TMEM174 TNIP1 TNIP3 TNK2 TNS4 TRAPPC14 TREX1 TRIM42 TSGA10IP TSPAN4 TTC23 TTPA TYK2 UBXN7 USP54 UTP23 VASN VENTX VGLL3 VSTM4 VWC2 VWC2L WDR25 WIF1 WNT11 WT1 YPEL3 YY1 ZBTB25 ZBTB4 ZCCHC14 ZDHHC1 ZFHX2 ZIC1 ZMYND10 ZNF124 ZNF266 ZNF319 ZNF330 ZNF34 ZNF408 ZNF414 ZNF417 ZNF419 ZNF438 ZNF439 ZNF440 ZNF441 ZNF446 ZNF497 ZNF552 ZNF575 ZNF580 ZNF581 ZNF587 ZNF648 ZNF669 ZNF683 ZNF696 ZNF764 ZNF775 ZNF786 ZNF835 ZNF837 ZNF843 ZNHIT1 ZSCAN5A	76 interacting genes: ACD ARRDC3 ATN1 ATXN7L2 BAIAP2L1 BCL2 CRYAB CTDSP1 CYSRT1 CYSTM1 DAZAP2 DNM2 DTX3 DVL1 DVL2 DYNLT1 EGR4 ENTREP1 EYA2 FAM168B FBXO7 FOXD4L1 GGN GLIS3 HELT HSPA1A HSPA5 HSPA8 HSPB2 HSPB2-C11orf52 HSPB7 HSPB8 INCA1 LENG8 LITAF LRRK1 LRRK2 MAGED1 MDFI MRPL38 NEDD8 NIBAN3 NOTO NR1H3 PDE9A PDLIM7 PIH1D2 PLA2G10 PLCG1 PLEKHB1 POT1 PRDM6 PRKAR1B PRR34 PTPN21 RUNX1 SF3B4 SHISA6 SIAH1 SPRY2 SRPK2 TBC1D3B TBC1D3G TINF2 TMEM174 TNK2 TP53BP2 TRIB3 TRIM27 TRIP6 TSC1 UBC UNKL VPS37B WBP2 WNK1
Entrez ID		375791	9531
HPRD ID		14696	04860
Ensembl ID		ENSG00000197191	ENSG00000151929
Uniprot IDs		A8MQ03	O95817
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Animal Organ Morphogenesis DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Structural Constituent Of Skin Epidermis	Ubiquitin Protein Ligase Binding Protein Refolding Telomere Assembly Regulation Of Protein Stability Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Signal Transduction Protein Folding Chaperone Complex Negative Regulation Of Signaling Negative Regulation Of Cell Communication Identical Protein Binding Telomere Capping Regulation Of Protein Ubiquitination Response To Unfolded Protein Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Primary Metabolic Process Cytoplasm Nucleus Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Metabolic Process Protein Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Intracellular Signal Transduction Protein Folding Chaperone Unfolded Protein Binding WW Domain Binding Convergent Extension Involved In Organogenesis C3HC4-type RING Finger Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Pancreatic Juice Secretion Intracellular Signal Transduction Regulation Of Membrane Permeability Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Convergent Extension Involved In Gastrulation ATP-dependent Protein Disaggregase Activity Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Folding Negative Regulation Of DNA Biosynthetic Process Regulation Of Apoptotic Signaling Pathway
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