FBXO2 and ECPAS

Number of citations of the paper that reports this interaction (PubMedID 20682791)
103

Data Source:
BioGRID (two hybrid)

		FBXO2	ECPAS
Description		F-box protein 2	Ecm29 proteasome adaptor and scaffold
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Membrane SCF Ubiquitin Ligase Complex Dendritic Spine Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Trans-Golgi Network Centrosome Cytoskeleton Membrane COPII-coated ER To Golgi Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle
	Molecular Function	Amyloid-beta Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding Denatured Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Molecular Adaptor Activity Proteasome Binding
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Glycoprotein Catabolic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Protein Modification Process ERAD Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission	ERAD Pathway Proteasome Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		16 interacting genes: AHSG BACE1 BRAP ECPAS IGH ITGB1 PAX4 PFDN6 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 VSTM1	36 interacting genes: AGTRAP ANK2 ANKRD17 BSND CCDC57 CEBPA CEP170B CKS1B CMTM5 CMTM6 CPD DGAT2L6 DNAJB9 DST FBXO2 GAREM2 GOLGB1 HNRNPM HSD17B13 HSPB1 MAL2 MKI67 MYH10 PCM1 PCYT1B RAB11FIP4 RNF168 SF3B2 SPECC1L SYNE1 TNFRSF10D UBE2G2 UBE2Q1 UIMC1 VPS11 ZNF483
Entrez ID		26232	23392
HPRD ID		06171	11078
Ensembl ID		ENSG00000116661	ENSG00000136813
Uniprot IDs		Q9UK22	A0AAA9X0G7 Q5VYK3
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Protein Autoubiquitination Protein Modification Process Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Vasoconstriction Positive Regulation Of Protein Ubiquitination Catabolic Process Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Folding Chaperone Complex Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Myoblast Fate Specification Integrin Alpha7-beta1 Complex Nucleoplasm Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Chaperone-mediated Protein Complex Assembly Multivesicular Body Golgi-associated Vesicle Lumen Negative Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Integrin Alpha6-beta1 Complex Regulation Of Vasoconstriction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Positive Regulation Of Programmed Cell Death Integrin Alpha1-beta1 Complex
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