FBXO2 and PFDN6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBXO2	PFDN6
Description		F-box protein 2	prefoldin subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Membrane SCF Ubiquitin Ligase Complex Dendritic Spine Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse	Cytoplasm Prefoldin Complex Protein-containing Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	Amyloid-beta Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding Denatured Protein Binding Ubiquitin Protein Ligase Activity	Amyloid-beta Binding Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Glycoprotein Catabolic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Protein Modification Process ERAD Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission	Protein Folding Protein Stabilization Chaperone-mediated Protein Complex Assembly Negative Regulation Of Amyloid Fibril Formation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		16 interacting genes: AHSG BACE1 BRAP ECPAS IGH ITGB1 PAX4 PFDN6 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3 VSTM1	13 interacting genes: AIMP2 B4GALT2 CCHCR1 CEBPA CEBPG FBXO2 KANK2 KIFC3 MAGEB4 MBD3 PFDN5 RPRD1B THAP11
Entrez ID		26232	10471
HPRD ID		06171	16135
Ensembl ID		ENSG00000116661	ENSG00000204220
Uniprot IDs		Q9UK22	O15212 Q5STK2
PDB IDs			6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Monoubiquitination Proteolysis Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Ubiquitin Protein Ligase Activity Protein Autoubiquitination Protein Modification Process Proteasomal Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Vasoconstriction Positive Regulation Of Protein Ubiquitination Catabolic Process Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Folding Chaperone Complex Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Myoblast Fate Specification Integrin Alpha7-beta1 Complex Nucleoplasm Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Chaperone-mediated Protein Complex Assembly Multivesicular Body Golgi-associated Vesicle Lumen Negative Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Integrin Alpha6-beta1 Complex Regulation Of Vasoconstriction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Positive Regulation Of Programmed Cell Death Integrin Alpha1-beta1 Complex
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