FBXO2 and AHSG

Number of citations of the paper that reports this interaction (PMID 12140560)
55

Data Source:
HPRD (in vivo)

		FBXO2	AHSG
Gene Name		F-box protein 2	alpha-2-HS-glycoprotein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol SCF Ubiquitin Ligase Complex Organelle Membrane Dendritic Spine Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Beta-amyloid Binding Glycoprotein Binding Ubiquitin-protein Transferase Activity Carbohydrate Binding	Cysteine-type Endopeptidase Inhibitor Activity Kinase Inhibitor Activity
	Biological Process	Cellular Protein Modification Process Proteolysis Glycoprotein Catabolic Process Negative Regulation Of Cell Proliferation Protein Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination	Skeletal System Development Ossification Pinocytosis Acute-phase Response Negative Regulation Of Endopeptidase Activity Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		11 interactors: AHSG BACE1 ITGB1 KIAA0368 SKP1 STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2L3	7 interactors: CDC42 DCN FBXO2 GRB2 INSR RRAS2 VKORC1
Entrez ID		26232	197
HPRD ID		06171	00727
Ensembl ID		ENSG00000116661	ENSG00000145192
Uniprot IDs		Q9UK22	P02765
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Polyubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Protein Ubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Monoubiquitination Response To Transforming Growth Factor Beta Positive Regulation Of Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway	Wound Healing Response To Wounding Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Exocrine System Development Positive Regulation Of DNA Replication Blood Coagulation Hemostasis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Body Fluid Levels Organ Development Regulation Of Mitotic Nuclear Division Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of DNA Replication Positive Regulation Of Cell Division Protein Heterooligomerization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of DNA Metabolic Process Tissue Development Insulin Receptor Signaling Pathway Actin Filament Branching Transformation Of Host Cell By Virus Submandibular Salivary Gland Formation Developmental Process Regulation Of Reactive Oxygen Species Metabolic Process Developmental Process Involved In Reproduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Placenta Development Positive Regulation Of T Cell Activation Cellular Response To Insulin Stimulus Establishment Of Golgi Localization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Ras Protein Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Process Leukocyte Migration Vitamin K Metabolic Process
Tagcloud ?		accumulate adaptor amyloid app box cleavage cleaving enriched facilitating glycans glycoprotein glycoproteins hippocampal hippocampi incompletely integral knock ligase mannose modulating neuron plasticity preferentially processing products secretase slices sought synapses	actual african americans associations caucasian caucasians causal diabetes directions fasting fetuin genetically glucose incident insignificant mendelian null predicted prevalent proxies raising randomization rs2248690 rs4917 sd snps trended unbiased variants
Tagcloud (Difference) ?		accumulate adaptor amyloid app box cleavage cleaving enriched facilitating glycans glycoprotein glycoproteins hippocampal hippocampi incompletely integral knock ligase mannose modulating neuron plasticity preferentially processing products secretase slices sought synapses	actual african americans associations caucasian caucasians causal diabetes directions fasting fetuin genetically glucose incident insignificant mendelian null predicted prevalent proxies raising randomization rs2248690 rs4917 sd snps trended unbiased variants
Tagcloud (Intersection) ?