RETREG3 and ACSL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RETREG3	ACSL5
Description		reticulophagy regulator family member 3	acyl-CoA synthetase long chain family member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Endoplasmic Reticulum Tubular Network	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Arachidonate-CoA Ligase Activity Oleoyl-CoA Ligase Activity
	Biological Process	Autophagy Endoplasmic Reticulum Organization Positive Regulation Of Neuron Projection Development Collagen Catabolic Process Reticulophagy Substrate Localization To Autophagosome Endoplasmic Reticulum Tubular Network Organization	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Positive Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Long-chain Fatty-acyl-CoA Biosynthetic Process Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Amyotrophic lateral sclerosis ( 32968195) Basophil percentage of white cells ( 32888494) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494)
Interacting Genes		107 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARLN ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6	13 interacting genes: AQP6 CREB3 EBAG9 FBXO7 PEX12 RETREG3 SELENOI SLC10A1 SLC10A6 SLC16A7 SLC35H1 SLC7A14 TMEM14B
Entrez ID		162427	51703
HPRD ID		14108	16139
Ensembl ID		ENSG00000141699	ENSG00000197142
Uniprot IDs		K7EQI9 Q86VR2	A0A8C8L3F5 Q9ULC5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Membrane Fusion Endomembrane System Organelle Fusion Organelle Membrane Fusion Membrane Organization Golgi Vesicle Transport Vesicle Fusion Protein Binding Organelle Localization By Membrane Tethering Vesicle Organization Lipid Biosynthetic Process Membrane Docking SNARE Binding Golgi Membrane Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Organization Vesicle Docking CDP-diacylglycerol Metabolic Process Transport Vesicle SNARE Complex Assembly Mitochondrial Outer Membrane Phosphatidylethanolamine Binding FFAT Motif Binding Endoplasmic Reticulum Membrane Organization Organelle Membrane Bounding Membrane Of Organelle Synaptic Vesicle Phospholipid Metabolic Process Azurophil Granule Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Phospholipid Biosynthetic Process Lipid Metabolic Process Establishment Of Protein Localization Late Endosome Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chloride Channel Inhibitor Activity Endoplasmic Reticulum Localization Serine Palmitoyltransferase Complex Positive Regulation Of B Cell Receptor Signaling Pathway	Transmembrane Transport Bile Acid:sodium Symporter Activity Organic Anion Transport Carboxylic Acid Transport Organic Acid Transport Symporter Activity Membrane Bile Acid And Bile Salt Transport Monocarboxylic Acid Transport Organic Hydroxy Compound Transport Nitrate Transmembrane Transporter Activity Pyruvate Secondary Active Transmembrane Transporter Activity Positive Regulation Of Deacetylase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Autophagy Secondary Active Monocarboxylate Transmembrane Transporter Activity Peroxisomal Importomer Complex Adaptive Immune Memory Response Involving T Cells And B Cells Lewy Body Core UDP-glucose Transmembrane Transport Ethanolaminephosphotransferase Activity Adaptive Immune Memory Response Pyruvate Transmembrane Transporter Activity Endoplasmic Reticulum-autophagosome Adaptor Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Peptidase Activator Activity Involved In Apoptotic Process Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Release From Viral Latency Protein O-linked Glycosylation Via Fucose Protein Import Into Peroxisome Matrix, Substrate Release Lactate Transmembrane Transporter Activity Pyruvate Transport CCR1 Chemokine Receptor Binding Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity
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