RETREG3 and PKMYT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RETREG3	PKMYT1
Description		reticulophagy regulator family member 3	protein kinase, membrane associated tyrosine/threonine 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Endoplasmic Reticulum Tubular Network	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Autophagy Endoplasmic Reticulum Organization Positive Regulation Of Neuron Projection Development Collagen Catabolic Process Reticulophagy Substrate Localization To Autophagosome Endoplasmic Reticulum Tubular Network Organization	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Meiotic Cell Cycle Negative Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways			Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint
Drugs			Fostamatinib
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Metabolic syndrome ( 20694148)
Interacting Genes		107 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARLN ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6	24 interacting genes: ABHD16A BCL2 CCNB1 CD3E CD79A CDK1 CLDN8 ELOVL4 FATE1 LIME1 LRRC25 MAPK10 MAPK8 PIN1 PLK1 RETREG3 SLC10A1 SLC30A8 SLC61A1 SLC71A2 STEAP3 TMEM101 TMEM229B TMX2
Entrez ID		162427	9088
HPRD ID		14108	03920
Ensembl ID		ENSG00000141699	ENSG00000127564
Uniprot IDs		K7EQI9 Q86VR2	Q0IJ49 Q99640
PDB IDs			3P1A 5VCV 5VCW 5VCX 5VCY 5VCZ 5VD0 5VD1 5VD3 8D6C 8D6D 8D6E 8D6F 8WJY 8ZTX 8ZU2 8ZUD 8ZUL
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Membrane Fusion Endomembrane System Organelle Fusion Organelle Membrane Fusion Membrane Organization Golgi Vesicle Transport Vesicle Fusion Protein Binding Organelle Localization By Membrane Tethering Vesicle Organization Lipid Biosynthetic Process Membrane Docking SNARE Binding Golgi Membrane Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Organization Vesicle Docking CDP-diacylglycerol Metabolic Process Transport Vesicle SNARE Complex Assembly Mitochondrial Outer Membrane Phosphatidylethanolamine Binding FFAT Motif Binding Endoplasmic Reticulum Membrane Organization Organelle Membrane Bounding Membrane Of Organelle Synaptic Vesicle Phospholipid Metabolic Process Azurophil Granule Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Phospholipid Biosynthetic Process Lipid Metabolic Process Establishment Of Protein Localization Late Endosome Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chloride Channel Inhibitor Activity Endoplasmic Reticulum Localization Serine Palmitoyltransferase Complex Positive Regulation Of B Cell Receptor Signaling Pathway	Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Cyclin B1-CDK1 Complex Protein Localization To Site Of Double-strand Break JUN Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport B Cell Receptor Complex Immune Response-regulating Signaling Pathway Mitotic Cell Cycle Phase Transition Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Striated Muscle Cell Development Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Membrane Disassembly Nuclear Membrane Disassembly MAP Kinase Activity Muscle Cell Development Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Toxic Substance Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Outer Kinetochore Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Peptidyl-threonine Phosphorylation Microtubule Polymerization Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Circadian Rhythm Fc-epsilon Receptor Signaling Pathway Lymphocyte Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle G2/M Phase Transition Mononuclear Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Endoplasmic Reticulum Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Chromosome Segregation Regulation Of Chromosome Segregation Cellular Response To Hypoxia Response To Iron Ion Positive Regulation Of Cell Cycle G2/M Phase Transition Response To Light Stimulus
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