RAN and RANBP1

Number of citations of the paper that reports this interaction (PMID 7891706)
16

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RAN	RANBP1
Gene Name		RAN, member RAS oncogene family	RAN binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Melanosome Recycling Endosome Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Poly(A) RNA Binding Androgen Receptor Binding	GDP-dissociation Inhibitor Activity GTPase Activator Activity Ran GTPase Binding
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization Mitotic Nuclear Division Signal Transduction Small GTPase Mediated Signal Transduction Spermatid Development Gene Expression Viral Process Viral Life Cycle Actin Cytoskeleton Organization Androgen Receptor Signaling Pathway Positive Regulation Of Protein Binding Cellular Protein Complex Localization Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Division Intracellular Transport Of Virus	Signal Transduction Viral Process Positive Regulation Of GTPase Activity Intracellular Transport Regulation Of Catalytic Activity
Pathways		Transcriptional regulation by small RNAs Metabolism of lipids and lipoproteins Nuclear import of Rev protein HIV Infection Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors MicroRNA (miRNA) biogenesis Influenza Infection Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Export of Viral Ribonucleoproteins from Nucleus HIV Life Cycle Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery	HIV Life Cycle Rev-mediated nuclear export of HIV RNA HIV Infection Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		55 interactors: ABL1 ADRB2 AR ASAP2 BCAR1 BMPR1B CSE1L EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KIAA1377 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUPR1 NUTF2 NXF1 NXT1 PAK4 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT	8 interactors: CD93 KPNB1 MDM2 NUPR1 RAN RANGRF RCC1 XPO1
Entrez ID		5901	5902
HPRD ID		03109	03110
Ensembl ID			ENSG00000099901
Uniprot IDs		B4DV51 P62826	B4DE76 D3DX26 P43487
PDB IDs		1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4	1K5D 1K5G
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Intracellular Transport Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Nuclear Import Protein Localization Cellular Localization Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cellular Protein Localization Protein Import Establishment Of Protein Localization To Organelle RNA Transport RNA Localization Protein Localization To Organelle Protein Targeting Protein Export From Nucleus Nuclear Export Transport Ribosomal Protein Import Into Nucleus Positive Regulation Of Ran GTPase Activity Viral Life Cycle MRNA Transport Cellular Response To Organic Substance Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly NLS-bearing Protein Import Into Nucleus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Cell Cycle Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Process Nuclear Envelope Organization Mitotic Cell Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Regulation Of Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Viral Transcription	Viral Process Intracellular Transport Of Virus Protein Localization To Nucleus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Subunit Export From Nucleus Protein Localization To Organelle Viral Life Cycle Cellular Protein Localization Regulation Of Protein Export From Nucleus Establishment Of Protein Localization Cytoplasmic Transport Protein Export From Nucleus Mitotic Cell Cycle Nucleocytoplasmic Transport Nuclear Transport Mitotic Spindle Organization Intracellular Protein Transport Regulation Of Cell Cycle Protein Localization Protein Exit From Endoplasmic Reticulum Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Cell Cycle Process Cellular Localization Cell Cycle Signal Transduction By P53 Class Mediator Nuclear Export Protein Transport Protein Import Into Nucleus Nuclear Import Spindle Organization Intracellular Transport Regulation Of Establishment Of Protein Localization Protein Import Mitotic Cell Cycle Process Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Response To Toxic Substance Regulation Of Membrane Depolarization During Action Potential Response To Vitamin B1 Response To Ether Ribosome Biogenesis Regulation Of Protein Localization Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Cell Surface Ribosomal Protein Import Into Nucleus Regulation Of Cardiac Muscle Cell Action Potential Establishment Of Localization In Cell
Tagcloud ?		5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced	antileukemic blocks chief crm1 deeper designated engrafted export groove immunodeficient kpt library mediator modeling nanomolar negligible nes occupied occupies orally penetrates potencies representative representing sine therapeutics virtual warrant
Tagcloud (Difference) ?		5a accessible actually arginine bandshift bi cargo characterised directional dissociated exports gtpase heterodimer import imported importin localisation masks multimeric nls nucleoplasm overlaps rab rev rip shuttle unspliced	antileukemic blocks chief crm1 deeper designated engrafted groove immunodeficient kpt library mediator modeling nanomolar negligible occupied occupies orally penetrates potencies representative representing sine therapeutics virtual warrant
Tagcloud (Intersection) ?		export nes