FBXW2 and EXOSC2

		FBXW2	EXOSC2
Description		F-box and WD repeat domain containing 2	exosome component 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Proteolysis Protein Modification Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		12 interacting genes: BTRC CDC34 CDK2 CLVS2 CTNNB1 CUL1 MSX2 MYB RELA SKP1 TRIM54 UBE2D2	18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408
Entrez ID		26190	23404
HPRD ID		09950	03758
Ensembl ID		ENSG00000119402	ENSG00000130713
Uniprot IDs		B4DT60 Q9UKT8	B3KQW2 Q13868
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Macromolecule Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Lysosome Organization Ubiquitin Ligase Complex Scaffold Activity Proteasomal Protein Catabolic Process Catabolic Process Negative Regulation Of Protein Sumoylation Transcription Regulator Complex Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Ubiquitin Ligase Activator Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Nucleoplasm Cellular Response To Interleukin-6 Protein Modification Process Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of T Cell Receptor Signaling Pathway Response To Interleukin-6 Cytosol Branching Morphogenesis Of An Epithelial Tube Proteolysis Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation Response To Muscle Stretch Morphogenesis Of A Branching Epithelium Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Hindlimb Morphogenesis Morphogenesis Of A Branching Structure Embryonic Forelimb Morphogenesis Non-canonical NF-kappaB Signal Transduction Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Metabolic Process	Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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