FBXW2 and CDC34

Number of citations of the paper that reports this interaction (PubMedID 10531035)
0

Data Source:
BioGRID (enzymatic study)

		FBXW2	CDC34
Description		F-box and WD repeat domain containing 2	cell division cycle 34, ubiquitin conjugating enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Proteolysis Protein Modification Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		12 interacting genes: BTRC CDC34 CDK2 CLVS2 CTNNB1 CUL1 MSX2 MYB RELA SKP1 TRIM54 UBE2D2	60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1
Entrez ID		26190	997
HPRD ID		09950	00306
Ensembl ID		ENSG00000119402	ENSG00000099804
Uniprot IDs		B4DT60 Q9UKT8	P49427
PDB IDs			2OB4 3RZ3 4MDK 7M2K 8RX0
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Macromolecule Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Lysosome Organization Ubiquitin Ligase Complex Scaffold Activity Proteasomal Protein Catabolic Process Catabolic Process Negative Regulation Of Protein Sumoylation Transcription Regulator Complex Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Ubiquitin Ligase Activator Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Nucleoplasm Cellular Response To Interleukin-6 Protein Modification Process Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of T Cell Receptor Signaling Pathway Response To Interleukin-6 Cytosol Branching Morphogenesis Of An Epithelial Tube Proteolysis Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation Response To Muscle Stretch Morphogenesis Of A Branching Epithelium Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Hindlimb Morphogenesis Morphogenesis Of A Branching Structure Embryonic Forelimb Morphogenesis Non-canonical NF-kappaB Signal Transduction Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Metabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction
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