PRPF31 and PRICKLE1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRPF31	PRICKLE1
Gene Name		pre-mRNA processing factor 31	prickle homolog 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex MLL1 Complex	Nucleus Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding Poly(A) RNA Binding SnRNP Binding	Protein Binding Zinc Ion Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome	Neural Tube Closure Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation
Pathways			Asymmetric localization of PCP proteins Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Heart failure ( 20445134) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		55 interactors: AES C1QTNF1 CALCOCO2 CCDC136 CCDC57 CDCA7L CEP70 FANCA GNB2L1 GOLGA2 HNRNPH2 HNRNPK JAKMIP2 KCTD6 KHDRBS2 KHDRBS3 KRT15 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LDOC1 LURAP1 MID2 MIPOL1 MKRN3 MTUS2 NHP2L1 NOTCH2NL PDE4DIP PHC2 PHF5A PNMA1 PNMA2 PPIH PRICKLE1 PRPF3 PRPF4 PSTPIP1 RBM25 RBM4 RBMY1A1 RBMY1F SIAH1 SSX2IP STX11 TADA2A TFIP11 TMCC2 TP53BP2 TRIM27 TSGA10 ZNF250 ZNF587	4 interactors: PRPF31 SMURF2 UTP14C VIP
Entrez ID		26121	144165
HPRD ID		05917	16341
Ensembl ID		ENSG00000105618	ENSG00000139174
Uniprot IDs		E7ESA8 F1T0A4 F1T0A5 Q8WWY3	B3KVG3 B3KVG6 Q96MT3
PDB IDs		2OZB 3SIU 3SIV
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Spermatogenesis Male Gamete Generation Negative Regulation Of Viral Release From Host Cell Regulation Of Gene Expression Regulation Of MRNA Processing Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of RNA Splicing Gamete Generation Protein Trimerization Spliceosomal Complex Disassembly Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Reproduction Sexual Reproduction Regulation Of Viral Process Multicellular Organismal Reproductive Process Regulation Of RNA Metabolic Process Multicellular Organism Reproduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Aldosterone Secretion Positive Regulation Of CAMP Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Protein Binding Positive Regulation Of Cell Death Single Organism Reproductive Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Cellular Component Assembly	Prolactin Secretion Ribonucleoprotein Complex Biogenesis Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Penile Erection Regulation Of Penile Erection Spliceosomal Tri-snRNP Complex Assembly
Tagcloud ?		ala78leufsx99 amplified autosomal chinese exons families frequencies harbor heterozygous hong kong missense modify nonpathogenic phe262serfsx59 pigmentosa pro347leu prph2 retina retinitis rho screen screened simplex stranded thirteen truncating woman	autonomously branchiomotor c251x caudal caudally cochlear dissimilar efferents fbm fbms laterally migrate modifies olivo orthologs pcp pial r4 r6 rhombomere ror2 separates vangl2 ventrally wnt5a
Tagcloud (Difference) ?		ala78leufsx99 amplified autosomal chinese exons families frequencies harbor heterozygous hong kong missense modify nonpathogenic phe262serfsx59 pigmentosa pro347leu prph2 retina retinitis rho screen screened simplex stranded thirteen truncating woman	autonomously branchiomotor c251x caudal caudally cochlear dissimilar efferents fbm fbms laterally migrate modifies olivo orthologs pcp pial r4 r6 rhombomere ror2 separates vangl2 ventrally wnt5a
Tagcloud (Intersection) ?