PRICKLE1 and BYSL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRICKLE1	BYSL
Description		prickle planar cell polarity protein 1	bystin like
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Postsynaptic Density Membrane Cell Trailing Edge Nuclear Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Membrane Preribosome, Small Subunit Precursor Apical Part Of Cell
	Molecular Function	Protein Binding Zinc Ion Binding Protein-containing Complex Binding Metal Ion Binding	RNA Binding Protein Binding SnoRNA Binding
	Biological Process	Neural Tube Closure Tissue Homeostasis Outflow Tract Morphogenesis Protein Import Into Nucleus Apoptotic Process Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Axonogenesis Heart Development Response To Xenobiotic Stimulus Animal Organ Morphogenesis Tissue Development Gene Expression Programmed Cell Death Wnt Signaling Pathway Vesicle-mediated Transport Dendrite Development Cell Migration Establishment Of Cell Polarity Bone Mineralization Embryonic Limb Morphogenesis Cytoskeleton-dependent Intracellular Transport Neuron Projection Development Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Limb Morphogenesis Multicellular Organism Growth Embryonic Nail Plate Morphogenesis Aorta Development Post-anal Tail Morphogenesis Embryonic Digit Morphogenesis Cilium Organization Establishment Of Protein Localization Negative Regulation Of DNA-templated Transcription Neuron Projection Morphogenesis Response To Electrical Stimulus Cardiac Muscle Cell Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Cilium Assembly Face Morphogenesis Mesenchyme Development Coronary Vasculature Development Eyelid Development In Camera-type Eye Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Cornea Development In Camera-type Eye Renal Tubule Development Polarized Secretion Of Basement Membrane Proteins In Epithelium Tear Secretion Basement Membrane Organization Extracellular Matrix Assembly Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Cell-cell Adhesion Regulation Of Postsynaptic Density Assembly Maintenance Of Postsynaptic Density Structure Focal Adhesion Disassembly Anterior Visceral Endoderm Cell Migration Neuron Projection Extension Embryonic Brain Development Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) In Utero Embryonic Development Blastocyst Formation Trophectodermal Cell Differentiation RRNA Processing Ribosome Biogenesis Stem Cell Proliferation Regulation Of Protein Localization To Nucleolus
Pathways		Asymmetric localization of PCP proteins	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Appendicular lean mass ( 33097823) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 30529582 31826910) Endometrial cancer (Non-endometrioid histology) ( 30093612) Graves' disease ( 22922229) Heart failure ( 20445134) Hip circumference adjusted for BMI ( 28552196) Impulsivity (non-planning) ( 30718321) Inferior parietal cortex volume ( 31530798) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Parkinson's disease ( 27182965) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 19862010 20139978) Mean corpuscular volume ( 19862010 20139978 23263863) Menarche (age at onset) ( 25231870 27182965) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Red blood cell count ( 20139978)
Interacting Genes		7 interacting genes: BYSL JRK KIF9 PRPF31 SMURF2 UTP14C VIP	138 interacting genes: AIMP2 AMOTL2 APP ATP5F1B AXIN2 BEND7 BFSP1 BHLHE40 C1orf94 CAVIN4 CCDC102B CCDC136 CCDC33 CDC23 CDCA7L CEP44 CEP57L1 CEP70 COIL DDX17 DOCK8 DRC4 DVL2 EAPP EIF4ENIF1 EMD EPS8 FAM228A FAM9B FCHO1 FXR1 FXR2 GMCL1 GOLGA2 GOLGA6L9 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 IKZF3 JRK KATNAL1 KIFC3 KLHL2 KLHL6 KRT31 KRT40 KRT8 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP4-2 L3MBTL3 LDOC1 LHX3 LMNA LMO1 LMO2 LONRF1 LZTS1 LZTS2 MB21D2 MCIDAS MEOX1 MEOX2 MID1 MID2 MIPOL1 MKRN1 MRFAP1L1 MTUS2 NECAB2 NF2 OGT OLIG3 OSBPL3 PDE4DIP PHC2 PICK1 PIH1D1 PNMA1 PNMA2 PRICKLE1 PSMC6 RACGAP1 RALY RALYL RBAK RP9 RUBCN SMN1 SMN2 SNW1 SSX2IP STX11 TBC1D26 TEKT1 TFIP11 THAP1 TLE5 TNIP1 TRAF2 TRAF4 TRAK1 TRIM14 TRIM27 TRIM37 TRIM38 TRIM41 TRIM54 TRIM55 TRIP6 TRO TROAP USH1G USO1 VIM VPS37B VPS52 WASF3 WTAP ZBTB14 ZBTB8A ZC2HC1C ZFP64 ZMAT5 ZNF212 ZNF286A ZNF426 ZNF438 ZNF48 ZNF655 ZNF668 ZNF71 ZNF835 ZSCAN22
Entrez ID		144165	705
HPRD ID		16341	04848
Ensembl ID		ENSG00000139174	ENSG00000112578
Uniprot IDs		B3KVG3 B3KVG6 Q96MT3	Q13895
PDB IDs			6G18 6G4S 6G4W 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Endocytosis Regulation Of Endocytosis Golgi-associated Vesicle Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dendrite Cytoplasm Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Clathrin Binding Lysosome Organization Positive Regulation Of Signal Transduction Regulation Of Vacuole Organization Regulation Of Vesicle-mediated Transport Tyrosinase Activity Eye Pigment Biosynthetic Process Regulation Of CAMP/PKA Signal Transduction Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Epinephrine Secretion Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Positive Regulation Of Clathrin Coat Assembly U4atac SnRNP Ribonucleoprotein Complex Localization ISWI-type Complex Regulation Of Locomotion Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Activation Of Blood Coagulation Via Clotting Cascade Phosphatidylserine Exposure On Blood Platelet Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Cell Population Proliferation Melanin Biosynthetic Process From Tyrosine Prolactin Secretion Regulation Of Wnt Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Identical Protein Binding Protein Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Microtubule Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Intermediate Filament Microtubule Binding Cytoplasm Cytoskeleton Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Keratin Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytosol Fibrillar Center TORC1 Complex Assembly Cellular Response To Muramyl Dipeptide Regulation Of Gene Expression Microtubule-based Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Organelle Organization Ubiquitin Protein Ligase Activity Cajal Body Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Segment Specification Negative Regulation Of Viral Transcription Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytoskeleton Organization Regulation Of Viral Transcription Centrosome Cycle Microtubule Organizing Center Organization Nuclear Pore Localization Transcription Coactivator Activity Somite Specification Cytoplasmic Ribonucleoprotein Granule Response To Muramyl Dipeptide Supramolecular Fiber Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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