PRPF31 and ZNF250

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF31	ZNF250
Description		pre-mRNA processing factor 31	zinc finger protein 250
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex Ribonucleoprotein Complex	Nucleus
	Molecular Function	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding SnRNP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing SnoRNA Localization Ribonucleoprotein Complex Localization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA Splicing - Major Pathway	Generic Transcription Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)	Logical memory (immediate recall) in normal cognition ( 29274321)
Interacting Genes		139 interacting genes: APOBEC3C ASB15 BICD2 C1QTNF1 CALCOCO2 CAPNS2 CARD14 CBY2 CCDC106 CCDC136 CCDC33 CCDC57 CCDC70 CCNDBP1 CDC23 CDCA7L CDR2L CEBPA CEP70 CYSRT1 DVL2 DVL3 EFEMP2 EIF3E EVI5 EXOSC8 FANCA FANCC FASTK FLACC1 FSD2 FXR1 GOLGA2 GOLGA6L9 GPRASP3 HAP1 HES7 HNRNPH2 HNRNPK HOOK2 HSF2BP JAKMIP2 KANK2 KCTD6 KHDRBS2 KHDRBS3 KIFC3 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP4-11 KRTAP6-3 LBX1 LDOC1 LHX8 LURAP1 LZTS2 MDFI MEIS3 MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NCKIPSD NOTCH2NLA OGT PAK5 PDE4DIP PHC2 PHF5A PICK1 PLEKHG4 PNMA1 PNMA2 PNMA3 PPIH PPP1R16A PPP2R3C PRDM14 PRICKLE1 PRPF3 PSTPIP1 RACK1 RBAK RBM25 RBM4 RBMX RBMY1A1 RBMY1F RBMY1J REL RINT1 RUNDC3A SIAH1 SLAIN1 SNRNP200 SRSF3 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM14 TRIM23 TRIM27 TRIM41 TSGA10 UBXN11 USH1G USP15 VWC2 ZFP64 ZFP69B ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF48 ZNF587 ZNF668 ZNF71 ZNF774 ZNF792 ZNF837 ZSCAN22	110 interacting genes: ANKRD50 APOBEC3C BEGAIN CARD10 CARD9 CBY2 CCDC102B CCDC125 CCDC136 CCDC6 CCDC85B CDCA7L CDR2 CDR2L CEP44 CEP63 CEP70 DPPA2 DRC3 DRC4 DVL2 FAM124A FAM161A FDXACB1 FHL5 GMCL1 GMNN GNPTAB GOLGA2 GOLGA6L9 GRAP2 GRIPAP1 GUCD1 HEXIM2 HMBOX1 HOMEZ HOOK1 HOOK2 HSF2BP KASH5 KIFC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 LDOC1 LMO2 LZTS1 LZTS2 MAGOHB MEOX2 MID2 MTUS2 MYF5 NDEL1 NEXN NINL NXF1 PIBF1 PICK1 PLEKHF2 PRDM14 PRPF31 RUBCN RUNDC3A SPECC1L SPRED2 SSX2IP STX1A SYNE4 TFF1 TMCC2 TNK1 TNNT1 TNS2 TOP3B TRAF1 TRAF2 TRIM23 TRIM27 TRIM41 TRIM54 UBE3A YJU2B ZBTB43 ZBTB6 ZBTB8A ZC4H2 ZCCHC13 ZCCHC7 ZFP1 ZNF165 ZNF175 ZNF202 ZNF330 ZNF345 ZNF460 ZNF473 ZNF547 ZNF57 ZNF572 ZNF639 ZNF648 ZNF668 ZNF768 ZNF792 ZNF837 ZRANB1
Entrez ID		26121	58500
HPRD ID		05917	15758
Ensembl ID		ENSG00000105618	ENSG00000196150
Uniprot IDs		Q8WWY3	B3KNS9 P15622
PDB IDs		2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament Keratin Filament Identical Protein Binding Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Spliceosomal Complex Regulation Of Nucleobase-containing Compound Metabolic Process Structural Constituent Of Skin Epidermis RNA Splicing Nucleic Acid Binding Regulation Of MRNA Metabolic Process Zinc Ion Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process RNA Processing Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression MRNA Binding Negative Regulation Of Viral Transcription Cytoskeleton Intermediate Filament Organization Positive Regulation Of RNA Splicing Regulation Of RNA Biosynthetic Process Regulation Of Viral Transcription	Protein Binding Zinc Ion Binding Identical Protein Binding Microtubule Binding Cytoskeleton Microtubule Regulation Of RNA Biosynthetic Process Centrosome Keratin Filament Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Metal Ion Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Microtubule-based Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Response To Muramyl Dipeptide CBM Complex FHF Complex Cytoskeleton Organization Intermediate Filament
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