ZNF451 and CPTP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNF451	CPTP
Description		zinc finger protein 451	ceramide-1-phosphate transfer protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Nucleus Nuclear Outer Membrane Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Sequence-specific DNA Binding Metal Ion Binding SUMO Ligase Activity Transcription Regulator Inhibitor Activity	Phospholipid Binding Lipid Binding Lipid Transfer Activity Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity
	Biological Process	Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription Initiation By RNA Polymerase II	Lipid Transport Negative Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Ceramide Transport Glycolipid Transport Intermembrane Lipid Transfer Negative Regulation Of NLRP3 Inflammasome Complex Assembly Ceramide 1-phosphate Transport
Pathways			Glycosphingolipid transport
Drugs
Diseases
GWAS
Interacting Genes		36 interacting genes: AR CALCOCO2 CBS CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUMO3 SUV39H1 UBC UBE2I ZBED1 ZNF467	7 interacting genes: CD7 ECM1 ELOC INPP5K PHF13 SMAD3 ZNF451
Entrez ID		26036	80772
HPRD ID		10332	18878
Ensembl ID		ENSG00000112200	ENSG00000224051
Uniprot IDs		B4DYS2 Q96JY2 Q9Y4E5	Q5TA50 S4S694
PDB IDs		5D2M	4K80 4K84 4K85 4K8N 4KBS 4KF6
Enriched GO Terms of Interacting Partners?		Protein Sumoylation PML Body SUMO Transferase Activity Protein Modification Process Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleus Protein Tag Activity Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity SUMO Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process S-adenosyl-L-methionine Binding Positive Regulation Of Catabolic Process Ubiquitin-like Protein Ligase Binding Protein Demethylase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Small Protein Activating Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Methyltransferase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Regulation Of Bone Mineralization Negative Regulation Of Ossification Transcription Corepressor Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Renal Water Transport Phosphatidylinositol Trisphosphate Phosphatase Activity Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Ossification Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Interleukin-2 Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Sterol Response Element Binding Carbohydrate Homeostasis Transdifferentiation Glucose Homeostasis Positive Regulation Of Transforming Growth Factor Beta3 Production SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Regulation Of Lung Blood Pressure Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Heteromeric SMAD Protein Complex Regulation Of Stress Fiber Assembly Trophoblast Cell Migration Immune System Development Regulation Of Transforming Growth Factor Beta2 Production Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Initiation Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Lipid Phosphatase Activity Inositol Bisphosphate Phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Negative Regulation Of Dephosphorylation Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Vasopressin Receptor Activity Negative Regulation Of Protein Targeting To Membrane Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response
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