ZNF451 and RNF40

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNF451	RNF40
Description		zinc finger protein 451	ring finger protein 40
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Sequence-specific DNA Binding Metal Ion Binding SUMO Ligase Activity Transcription Regulator Inhibitor Activity	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription Initiation By RNA Polymerase II	Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		36 interacting genes: AR CALCOCO2 CBS CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUMO3 SUV39H1 UBC UBE2I ZBED1 ZNF467	27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DUSP29 EEF1D H2AC4 H2BC3 ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL PKNOX1 RB1 RPA1 RPA2 TRIM51 UBE2A UBE2B UBE2D2 UBE2I UBE2L6 ZCCHC12 ZNF451
Entrez ID		26036	9810
HPRD ID		10332	07411
Ensembl ID		ENSG00000112200	ENSG00000103549
Uniprot IDs		B4DYS2 Q96JY2 Q9Y4E5	A8K6K1 O75150
PDB IDs		5D2M	8GUI 8GUJ 8IEJ
Enriched GO Terms of Interacting Partners?		Protein Sumoylation PML Body SUMO Transferase Activity Protein Modification Process Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleus Protein Tag Activity Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity SUMO Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process S-adenosyl-L-methionine Binding Positive Regulation Of Catabolic Process Ubiquitin-like Protein Ligase Binding Protein Demethylase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Small Protein Activating Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Methyltransferase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Protein Localization To Chromosome PML Body Ubiquitin-like Protein Transferase Activity Chromosome, Telomeric Region Positive Regulation Of MRNA 3'-end Processing HULC Complex Chromatin Organization Nucleus Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Modification By Small Protein Conjugation Protein Polyubiquitination Telomere Localization Regulation Of MRNA 3'-end Processing G-rich Strand Telomeric DNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition DNA Replication Factor A Complex Chromosome Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Site Of Double-strand Break Chromatin Remodeling Telomere Maintenance Proteolysis Involved In Protein Catabolic Process Histone MRNA Metabolic Process Response To Radiation Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Site Of Double-strand Break Sperm Axoneme Assembly Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Mismatch Repair Telomere Organization DNA Repair MRNA 3'-end Processing Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Recombinational Repair Regulation Of DNA Recombination Positive Regulation Of RNA Binding
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