ZNF451 and CDCA4

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		ZNF451	CDCA4
Description		zinc finger protein 451	cell division cycle associated 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Sequence-specific DNA Binding Metal Ion Binding SUMO Ligase Activity Transcription Regulator Inhibitor Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription Initiation By RNA Polymerase II	Positive Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS			Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Leukocyte telomere length ( 32109421)
Interacting Genes		36 interacting genes: AR CALCOCO2 CBS CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A KLHL40 LZTR1 MID2 OPLAH PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUMO3 SUV39H1 UBC UBE2I ZBED1 ZNF467	25 interacting genes: AIRIM BFSP2 DOK5 ENKD1 FAM222B FARS2 FNDC11 KAT2B KDM1A KLHL42 MKRN3 PARD6B PRMT6 SEPHS1 SHC3 SUOX SUPT7L SUV39H1 SUV39H2 TCAP TRIM28 TXN2 XPO1 YPEL3 ZNF451
Entrez ID		26036	55038
HPRD ID		10332	13015
Ensembl ID		ENSG00000112200	ENSG00000170779
Uniprot IDs		B4DYS2 Q96JY2 Q9Y4E5	Q9BXL8
PDB IDs		5D2M
Enriched GO Terms of Interacting Partners?		Protein Sumoylation PML Body SUMO Transferase Activity Protein Modification Process Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Nucleus Protein Tag Activity Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Positive Regulation Of RNA Metabolic Process Transcription Coactivator Activity SUMO Ligase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process S-adenosyl-L-methionine Binding Positive Regulation Of Catabolic Process Ubiquitin-like Protein Ligase Binding Protein Demethylase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Small Protein Activating Enzyme Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Methyltransferase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Epigenetic Programming Of Gene Expression Histone H3K9 Trimethyltransferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Regulation Of DNA Repair Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Transcription By Glucose Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Binding I Band SAGA Complex Transcription Coactivator Activity Regulation Of Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization
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