NSMF and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NSMF	PTPN21
Description		NMDA receptor synaptonuclear signaling and neuronal migration factor	protein tyrosine phosphatase non-receptor type 21
Image		No pdb structure
GO Annotations	Cellular Component	Euchromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Nuclear Matrix Dendrite Cortical Cytoskeleton Nuclear Membrane Cell Projection Neuron Projection Perikaryon Synapse Apical Dendrite	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Regulation Of Neuron Apoptotic Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Dendrite Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Electrical Stimulus Cellular Response To Gonadotropin Stimulus Regulation Of Neuron Migration Positive Regulation Of Neuron Migration	Protein Dephosphorylation
Pathways
Drugs
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS			Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		24 interacting genes: CALM1 CALM2 CALM3 CCDC125 CCNDBP1 GFI1B GOLGA2 GOLGA6L9 HSF2BP HSPB3 INTS11 KIFC3 LMO2 LXN MID2 MYL12B PNMA1 PTPN21 RAN SOCS7 TFIP11 TRIP6 UBASH3A VPS26C	27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		26012	11099
HPRD ID		10485	04468
Ensembl ID		ENSG00000165802	ENSG00000070778
Uniprot IDs		A8K7L5 Q6X4W1	Q16825
PDB IDs			8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Positive Regulation Of Sequestering Of Calcium Ion Sperm Midpiece Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Cytoplasm Sarcomere Spindle Pole Importin-alpha Family Protein Binding Neural Nucleus Development Adenylate Cyclase Binding Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Calcium Channel Inhibitor Activity Voltage-gated Potassium Channel Complex Regulation Of Voltage-gated Calcium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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