NSMF and MYL12B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NSMF	MYL12B
Description		NMDA receptor synaptonuclear signaling and neuronal migration factor	myosin light chain 12B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Euchromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Nuclear Matrix Dendrite Cortical Cytoskeleton Nuclear Membrane Cell Projection Neuron Projection Perikaryon Synapse Apical Dendrite	Stress Fiber Cytoplasm Cytosol Brush Border Cell Cortex Myosin Complex Myosin II Complex Myofibril Z Disc Protein-containing Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding Myosin Heavy Chain Binding Metal Ion Binding
	Biological Process	Regulation Of Neuron Apoptotic Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Dendrite Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Electrical Stimulus Cellular Response To Gonadotropin Stimulus Regulation Of Neuron Migration Positive Regulation Of Neuron Migration	Regulation Of Cell Shape
Pathways			EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS			Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		24 interacting genes: CALM1 CALM2 CALM3 CCDC125 CCNDBP1 GFI1B GOLGA2 GOLGA6L9 HSF2BP HSPB3 INTS11 KIFC3 LMO2 LXN MID2 MYL12B PNMA1 PTPN21 RAN SOCS7 TFIP11 TRIP6 UBASH3A VPS26C	5 interacting genes: DAPK1 HSPB1 MYLIP NSMF PNKD
Entrez ID		26012	103910
HPRD ID		10485	10095
Ensembl ID		ENSG00000165802	ENSG00000118680
Uniprot IDs		A8K7L5 Q6X4W1	O14950
PDB IDs
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Positive Regulation Of Sequestering Of Calcium Ion Sperm Midpiece Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Cytoplasm Sarcomere Spindle Pole Importin-alpha Family Protein Binding Neural Nucleus Development Adenylate Cyclase Binding Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Calcium Channel Inhibitor Activity Voltage-gated Potassium Channel Complex Regulation Of Voltage-gated Calcium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Protein Kinase C Signaling Regulation Of NMDA Receptor Activity Plasma Membrane Protein Kinase C Inhibitor Activity Hydroxyacylglutathione Hydrolase Activity Methylglyoxal Catabolic Process To Lactate Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To D-lactate Via S-lactoyl-glutathione Regulation Of Programmed Cell Death Cellular Response To Hydroperoxide Regulation Of Apoptotic Process Postsynaptic Density Defense Response To Tumor Cell Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Regulation Of Translation Regulation Of Autophagy Cytoskeleton Regulation Of Neurotransmitter Receptor Activity Syntaxin-1 Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Contractile Muscle Fiber Lactate Metabolic Process Methylglyoxal Metabolic Process Regulation Of Synaptic Transmission, Dopaminergic Aldehyde Catabolic Process Regulation Of Dopamine Metabolic Process Ketone Catabolic Process Cellular Detoxification Of Aldehyde Neuromuscular Process Controlling Posture Negative Regulation Of Neurotransmitter Secretion Apical Dendrite Regulation Of Neuron Projection Development Positive Regulation Of Neuron Migration Cellular Response To Electrical Stimulus Cellular Response To Gonadotropin Stimulus Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Refolding Presynaptic Cytosol
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