EGFL6 and SH3GL2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		EGFL6	SH3GL2
Description		EGF like domain multiple 6	SH3 domain containing GRB2 like 2, endophilin A1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Membrane Extracellular Matrix	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Differentiation Extracellular Matrix Organization	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways			Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Multiple sclerosis ( 23412934)	Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		3 interacting genes: SH3GL2 SH3GL3 UBQLN2	53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		25975	6456
HPRD ID		02212	05125
Ensembl ID		ENSG00000198759	ENSG00000107295
Uniprot IDs		Q8IUX8	Q99962
PDB IDs			1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Receptor-mediated Endocytosis Regulation Of Clathrin-dependent Endocytosis Regulation Of Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Identical Protein Binding Regulation Of Vesicle-mediated Transport Negative Regulation Of Endocytosis Central Nervous System Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Blood-brain Barrier Permeability Presynapse Postsynaptic Endosome Photoreceptor Ribbon Synapse Early Endosome Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus Body Morphogenesis Embryonic Body Morphogenesis Lipid Binding Dendrite Extension Regulation Of Transport Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Endocytosis Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Vascular Permeability Postsynaptic Density, Intracellular Component Negative Regulation Of Transport Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Postsynaptic Cytoskeleton Organization Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Centriole Replication Regulation Of ERAD Pathway Glutamatergic Synapse Presynaptic Cytosol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Centriole Assembly Import Into Cell Negative Regulation Of ERBB Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Gamma-tubulin Binding Organelle Organization Presynaptic Endocytosis Regulation Of Cellular Component Organization Response To Nerve Growth Factor Regulation Of Vascular Permeability Endosome	Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle
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