FOXK2 and IL2

Number of citations: 0 (PubMedID 9065434)
Data Source: HPRD (in vitro)

		FOXK2	IL2
Name		forkhead box K2	interleukin 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion	Extracellular Region Extracellular Space
	Molecular Function	Magnesium Ion Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Cytokine Activity Interleukin-2 Receptor Binding Protein Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Response To Starvation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Canonical Glycolysis	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Apoptotic Process Transcription By RNA Polymerase II Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Gene Expression Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Interleukin-2-mediated Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Plasma Cell Differentiation Response To Tacrolimus Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		UCH proteinases	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		None	Pseudoephedrine Cefazolin SP4160 N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid SP2456 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide Keyhole limpet hemocyanin Girentuximab TG4010
Diseases		None	Graft-versus-host disease Type I diabetes mellitus
GWAS		Appendicular lean mass ( 33097823 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Lean body mass ( 28552196 ) Letter-number span reordering ( 31596458 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red cell distribution width ( 28957414 27863252 32888494 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 30013184 23817571 ) Allergy ( 27182965 ) Alopecia areata ( 25608926 20596022 ) Asthma ( 31619474 31361310 31959851 30929738 ) Asthma (adult onset) ( 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 25574825 23727859 26482879 ) Bipolar disorder ( 31043756 ) Celiac disease ( 24999842 25920553 22057235 20190752 17558408 18311140 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) IgE grass sensitization ( 22036096 ) Inflammatory bowel disease ( 28067908 23128233 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Medication use (adrenergics, inhalants) ( 31015401 ) Primary sclerosing cholangitis ( 27992413 23603763 ) Progressive supranuclear palsy ( 21685912 ) Rheumatoid arthritis ( 30423114 24390342 ) Selective IgA deficiency ( 27723758 ) Systemic lupus erythematosus ( 28714469 ) Type 1 diabetes ( 19430480 21829393 25751624 ) Ulcerative colitis ( 21297633 ) Vaso-occlusive pain in sickle-cell anemia ( 28584135 )
Novel Interactors		None recorded	1 novel interactors: FGF2
Interacting Genes		9 interacting genes: ESR1 HCFC1 IL2 MTA3 RBBP4 RCOR1 SIN3A TBL1X TBL1XR1	9 interacting genes: CD53 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR S100A6 SHC1
Entrez ID		3607	3558
HPRD ID		00982	00979
Ensembl ID		ENSG00000141568	ENSG00000109471
Uniprot IDs		Q01167	P60568 Q0GK43
PDB IDs		1JXS 2C6Y	1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E 5UTZ 6LX3 6LXW 6VWU 6YE3 7DR4 7M2G 7RA9 7RAA 7YZJ 7ZMZ 8SOW 8SOZ 8WYR 8WYS
GO Terms Enriched among Interactors		Histone Deacetylase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization Transcription Repressor Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process NuRD Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Sin3-type Complex Positive Regulation Of Biosynthetic Process Regulation Of Cell Fate Specification Regulation Of Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Histone Binding Blastocyst Hatching Histone Methyltransferase Complex Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Regulation Of Cell Fate Commitment Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Protein-containing Complex Regulation Of Developmental Process Kappa-type Opioid Receptor Binding	Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2-mediated Signaling Pathway Interleukin-2 Receptor Complex Interleukin-15 Receptor Activity Cell Surface Receptor Signaling Pathway Coreceptor Activity Interleukin-15-mediated Signaling Pathway Signal Transduction Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Cytokine Receptor Activity Positive Regulation Of Developmental Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Animal Organ Morphogenesis Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation External Side Of Plasma Membrane Positive Regulation Of Phagocytosis Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Intracellular Glucose Homeostasis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration Positive Regulation Of Cell Development Corticotropin Hormone Secreting Cell Differentiation