SOSTDC1 and BMP7

Number of citations of the paper that reports this interaction (PMID 14623234)
38

Data Source:
HPRD (in vivo, in vitro)

		SOSTDC1	BMP7
Gene Name		sclerostin domain containing 1	bone morphogenetic protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Space Extracellular Matrix Membrane-bounded Vesicle
	Molecular Function		Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding BMP Receptor Binding
	Biological Process	Pattern Specification Process Negative Regulation Of Cell Fate Commitment Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Odontogenesis Of Dentin-containing Tooth Mammary Gland Bud Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway	Skeletal System Development Ossification Metanephros Development Ureteric Bud Development Mesoderm Formation Mesonephros Development Epithelial To Mesenchymal Transition Axon Guidance Embryonic Pattern Specification Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Dendrite Development Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Protein Localization To Nucleus Growth Negative Regulation Of Phosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Response To Peptide Hormone Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Cartilage Development Embryonic Skeletal Joint Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Cell Death Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Regulation Of Removal Of Superoxide Radicals
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)	Response to citalopram treatment ( 19846067) White blood cell types ( 21738478)
Protein-Protein Interactions		5 interactors: BMP2 BMP4 BMP6 BMP7 CDC20	21 interactors: ACTN4 ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 ENG GDF7 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP5-9 MTUS2 NCOA3 NOG NOTCH2NL SOSTDC1 TRIM27
Entrez ID		25928	655
HPRD ID		15417	00212
Ensembl ID		ENSG00000171243	ENSG00000101144
Uniprot IDs		A4D125 A8MUA6 Q6X4U4	A8K571 P18075
PDB IDs			1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Cell Proliferation Involved In Kidney Development Positive Regulation Of Ossification Mesenchymal Cell Proliferation Regulation Of Osteoblast Differentiation Regulation Of Neuron Differentiation Cartilage Development Regulation Of Ossification Regulation Of Neurogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Regulation Of Cell Development Glandular Epithelial Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Organ Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Glomerulus Development BMP Signaling Pathway Involved In Heart Induction Ossification Kidney Development Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Neuron Differentiation Renal System Development Positive Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Involved In Heart Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Urogenital System Development Negative Regulation Of Cell Division Positive Regulation Of Protein Metabolic Process Positive Regulation Of Neurogenesis Regulation Of Endothelial Cell Proliferation Stem Cell Proliferation Regulation Of Cartilage Development Negative Regulation Of Cell Cycle Regulation Of Glomerular Mesangial Cell Proliferation Odontogenesis Of Dentin-containing Tooth Growth Positive Regulation Of Cell Development Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis	BMP Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Tissue Development Regulation Of Osteoblast Differentiation Pattern Specification Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Regulation Of Ossification Positive Regulation Of Ossification Embryonic Morphogenesis Organ Morphogenesis Tube Development Epithelium Development Mesoderm Development Skeletal System Development Enzyme Linked Receptor Protein Signaling Pathway Gastrulation Regulation Of Transcription From RNA Polymerase II Promoter Tissue Morphogenesis Tube Morphogenesis Regulation Of Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Differentiation Embryo Development Signal Transduction By Phosphorylation Organ Development Regulation Of Signaling Positive Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Phosphorylation Protein Phosphorylation Signal Transduction Developmental Process Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Signaling Cartilage Development Venous Blood Vessel Development Cell Communication Endothelial Cell Differentiation Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development
Tagcloud ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome serpini1 silac silico spectrometer tnfsf9 tumorigenic velos zg16b	antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff
Tagcloud (Difference) ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome serpini1 silac silico spectrometer tnfsf9 tumorigenic velos zg16b	antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff
Tagcloud (Intersection) ?