SOSTDC1 and BMP6

Number of citations of the paper that reports this interaction (PubMedID 14623234)
0

Data Source:
HPRD (in vitro)

		SOSTDC1	BMP6
Description		sclerostin domain containing 1	bone morphogenetic protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Vesicle Enzyme Activator Complex
	Molecular Function	BMP Binding BMP Receptor Activity	Cytokine Activity Protein Binding Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Pattern Specification Process Negative Regulation Of Cell Fate Commitment Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Odontogenesis Of Dentin-containing Tooth Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Canonical Wnt Signaling Pathway Mammary Gland Bud Morphogenesis Epithelial Cell Fate Commitment Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Determination Of Dorsal Identity	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Intracellular Iron Ion Homeostasis Inflammatory Response Immune Response Heart Development Positive Regulation Of Cell Population Proliferation Tissue Development Response To Iron Ion Positive Regulation Of Gene Expression Response To Activity Cell Differentiation Neuron Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Developmental Process Cartilage Development Response To Glucocorticoid Bone Development Positive Regulation Of SMAD Protein Signal Transduction Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion
Pathways
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 20881960 31562340 18391951 28552196 25429064 25282103 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Platelet count ( 32888494) Pulse pressure ( 30578418 27841878) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730) Spondylosis ( 33332786) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: BMP2 BMP4 BMP6 BMP7 CDC20	11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 CRIPTO NCOA3 SMAD5 SOSTDC1
Entrez ID		25928	654
HPRD ID		15417	00211
Ensembl ID		ENSG00000171243	ENSG00000153162
Uniprot IDs		A4D125 Q6X4U4	B4DUF7 P22004 Q4VBA3
PDB IDs			2QCW 2R52 2R53 6OMO
Enriched GO Terms of Interacting Partners?		BMP Receptor Binding Cellular Response To BMP Stimulus Positive Regulation Of Bone Mineralization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Ameloblast Differentiation Positive Regulation Of Epithelial Cell Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Neuron Differentiation Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Osteoblast Differentiation Ossification Regulation Of Osteoblast Differentiation Growth Factor Activity Regulation Of Epithelial Cell Differentiation Regulation Of Animal Organ Formation Positive Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Skeletal System Development Regulation Of Neuron Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytokine Activity Negative Regulation Of Mitotic Nuclear Division Enzyme Activator Complex Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Heart Development Cellular Response To Growth Factor Stimulus Mesenchyme Development Cardiac Jelly Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Prostatic Bud Formation Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Odontogenesis Of Dentin-containing Tooth Bone Development Protein Serine/threonine Kinase Activator Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Cartilage Development System Development Negative Regulation Of Cell Cycle Regulation Of Animal Organ Morphogenesis	BMP Receptor Activity BMP Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Binding Positive Regulation Of Osteoblast Differentiation Cellular Response To BMP Stimulus Enzyme-linked Receptor Protein Signaling Pathway Pattern Specification Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Regulation Of Bone Mineralization Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Regulation Of Ossification Mitral Valve Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Developmental Process Positive Regulation Of Developmental Process Atrioventricular Valve Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Signal Transduction Animal Organ Development Anatomical Structure Morphogenesis Cartilage Development Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Developmental Process Regulation Of Cell Communication Regulation Of Signaling Activin Receptor Activity, Type II Developmental Process Ventricular Septum Morphogenesis Tissue Development Mullerian Duct Regression Tricuspid Valve Morphogenesis Anterior/posterior Pattern Specification Growth Factor Binding Protein Serine/threonine Kinase Activity
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