SOSTDC1 and CDC20

Number of citations of the paper that reports this interaction (PMID 15280373)
10

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SOSTDC1	CDC20
Gene Name		sclerostin domain containing 1	cell division cycle 20
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Spindle Pole Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function		Protein Binding Protein C-terminus Binding Enzyme Binding
	Biological Process	Pattern Specification Process Negative Regulation Of Cell Fate Commitment Wnt Signaling Pathway Negative Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Odontogenesis Of Dentin-containing Tooth Mammary Gland Bud Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway	Mitotic Cell Cycle Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiosis Regulation Of Dendrite Development Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synapse Maturation
Pathways			Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Phosphorylation of Emi1 Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)
Protein-Protein Interactions		5 interactors: BMP2 BMP4 BMP6 BMP7 CDC20	37 interactors: ANAPC1 ANAPC10 ANAPC2 ANAPC5 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CDC16 CDC27 CDC6 CDR2 CDT1 FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 MAD2L1 MAD2L2 PIM1 PLK1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 UBE2C UBE2S
Entrez ID		25928	991
HPRD ID		15417	04686
Ensembl ID		ENSG00000171243	ENSG00000117399
Uniprot IDs		A4D125 A8MUA6 Q6X4U4	Q12834
PDB IDs			4GGA 4GGC 4GGD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Cell Proliferation Involved In Kidney Development Positive Regulation Of Ossification Mesenchymal Cell Proliferation Regulation Of Osteoblast Differentiation Regulation Of Neuron Differentiation Cartilage Development Regulation Of Ossification Regulation Of Neurogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Regulation Of Cell Development Glandular Epithelial Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Organ Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Glomerulus Development BMP Signaling Pathway Involved In Heart Induction Ossification Kidney Development Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Neuron Differentiation Renal System Development Positive Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Involved In Heart Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Urogenital System Development Negative Regulation Of Cell Division Positive Regulation Of Protein Metabolic Process Positive Regulation Of Neurogenesis Regulation Of Endothelial Cell Proliferation Stem Cell Proliferation Regulation Of Cartilage Development Negative Regulation Of Cell Cycle Regulation Of Glomerular Mesangial Cell Proliferation Odontogenesis Of Dentin-containing Tooth Growth Positive Regulation Of Cell Development Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis	Regulation Of Cell Cycle Mitotic Nuclear Division Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Regulation Of Protein Ubiquitination Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Chromosome Organization Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome serpini1 silac silico spectrometer tnfsf9 tumorigenic velos zg16b	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Difference) ?		a9 cd137l colonization ctss dataset deregulated discriminate efna3 elisas forward gdf15 isotope km12c km12sm metastatic midkine neo1 orbitrap podxl s100a8 secretome serpini1 silac silico spectrometer tnfsf9 tumorigenic velos zg16b	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Intersection) ?