MRGPRX1 and GNG2

Number of citations of the paper that reports this interaction (PMID 15782186)
67

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MRGPRX1	GNG2
Gene Name		MAS-related GPR, member X1	guanine nucleotide binding protein (G protein), gamma 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity	Signal Transducer Activity G-protein Beta-subunit Binding
	Biological Process	Acute-phase Response G-protein Coupled Receptor Signaling Pathway	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus
Pathways			Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs			Halothane
Diseases
GWAS			Non-melanoma skin cancer ( 23548203)
Protein-Protein Interactions		4 interactors: GNAI2 GNAQ GNB1 GNG2	15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R
Entrez ID		259249	54331
HPRD ID		06246	16234
Ensembl ID		ENSG00000170255	ENSG00000186469
Uniprot IDs		Q96LB2	P59768
PDB IDs			4KFM
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus G-protein Coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Fatty Acid Response To Glucagon Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Fatty Acid Synaptic Transmission Cell Proliferation Energy Reserve Metabolic Process Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Acid Chemical Response To Stress Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cardiac Muscle Cell Apoptotic Process Cellular Response To Peptide Muscle Cell Apoptotic Process Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Cellular Response To Organic Cyclic Compound Generation Of Precursor Metabolites And Energy Cellular Response To Lipid Regulation Of Melanocyte Differentiation Response To Peptide Hormone Adenosine Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Signal Transduction Response To Peptide Maternal Behavior Signaling Cellular Response To Hormone Stimulus Cell Communication	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure
Tagcloud ?			abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Difference) ?			abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh
Tagcloud (Intersection) ?