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MRGPRX1 and GNB1
Number of citations of the paper that reports this interaction (PMID
15782186
)
67
Data Source:
BioGRID
(fluorescent resonance energy transfer)
MRGPRX1
GNB1
Gene Name
MAS-related GPR, member X1
guanine nucleotide binding protein (G protein), beta polypeptide 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Photoreceptor Inner Segment
Intracellular
Lysosomal Membrane
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Dendrite
Vesicle
Photoreceptor Outer Segment Membrane
Cell Body
Extracellular Vesicular Exosome
Photoreceptor Disc Membrane
Molecular Function
G-protein Coupled Receptor Activity
GTPase Activity
Signal Transducer Activity
Protein Binding
Spectrin Binding
Type 1 Angiotensin Receptor Binding
Protein Complex Binding
GTPase Binding
Biological Process
Acute-phase Response
G-protein Coupled Receptor Signaling Pathway
Energy Reserve Metabolic Process
Signal Transduction
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Ras Protein Signal Transduction
Synaptic Transmission
Blood Coagulation
Phototransduction, Visible Light
Cell Proliferation
Cardiac Muscle Cell Apoptotic Process
Rhodopsin Mediated Signaling Pathway
Regulation Of Rhodopsin Mediated Signaling Pathway
Platelet Activation
Small Molecule Metabolic Process
Sensory Perception Of Taste
Retina Development In Camera-type Eye
Cellular Response To Glucagon Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Hypoxia
Cellular Response To Catecholamine Stimulus
Pathways
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
G alpha (s) signalling events
Activation of GABAB receptors
Glucagon-type ligand receptors
G beta:gamma signalling through PLC beta
Signaling by Wnt
Metabolic disorders of biological oxidation enzymes
G protein gated Potassium channels
Olfactory Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ADP signalling through P2Y purinoceptor 12
Glucagon signaling in metabolic regulation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Inwardly rectifying K+ channels
G-protein beta:gamma signalling
Opioid Signalling
Activation of Kainate Receptors upon glutamate binding
Diseases associated with visual transduction
Aquaporin-mediated transport
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (q) signalling events
GPCR downstream signaling
Platelet homeostasis
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
G alpha (q) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signal amplification
Potassium Channels
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
G beta:gamma signalling through PI3Kgamma
The phototransduction cascade
G alpha (12/13) signalling events
Class B/2 (Secretin family receptors)
Prostacyclin signalling through prostacyclin receptor
GABA B receptor activation
GABA receptor activation
Activation of G protein gated Potassium channels
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
GPCR ligand binding
beta-catenin independent WNT signaling
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Visual phototransduction
Ca2+ pathway
G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
GNAI2
GNAQ
GNB1
GNG2
43 interactors:
ADRA2A
ADRB2
ADRBK1
AFP
ARHGEF18
ARRB1
ATXN10
AVPR2
CACNA1A
CACNA1B
CACNA1C
CYFIP1
DISC1
EPHA7
GNA12
GNAS
GNB2L1
GNG10
GNG11
GNG12
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNG8
GNGT1
HDAC4
HDAC5
KCNJ3
MCF2
MRGPRX1
MTNR1A
MTNR1B
NOL11
NR3C1
PDCL
PLEKHG2
PTH1R
RASD1
RASD2
TBXA2R
Entrez ID
259249
2782
HPRD ID
06246
00766
Ensembl ID
ENSG00000170255
ENSG00000078369
Uniprot IDs
Q96LB2
P62873
PDB IDs
4KFM
Enriched GO Terms of Interacting Partners
?
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Platelet Activation
Dopamine Receptor Signaling Pathway
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Cellular Response To Prostaglandin E Stimulus
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Response To Prostaglandin E
Cellular Response To Prostaglandin Stimulus
G-protein Coupled Receptor Signaling Pathway
Cellular Response To Catecholamine Stimulus
Cellular Response To Glucagon Stimulus
Cellular Response To Fatty Acid
Response To Glucagon
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Response To Fatty Acid
Synaptic Transmission
Cell Proliferation
Energy Reserve Metabolic Process
Cell-cell Signaling
Cell Surface Receptor Signaling Pathway
Cellular Response To Acid Chemical
Response To Stress
Energy Derivation By Oxidation Of Organic Compounds
Cellular Response To Peptide Hormone Stimulus
Cardiac Muscle Cell Apoptotic Process
Cellular Response To Peptide
Muscle Cell Apoptotic Process
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Neuron Remodeling
Cellular Response To Organic Cyclic Compound
Generation Of Precursor Metabolites And Energy
Cellular Response To Lipid
Regulation Of Melanocyte Differentiation
Response To Peptide Hormone
Adenosine Receptor Signaling Pathway
Cellular Response To Organonitrogen Compound
Signal Transduction
Response To Peptide
Maternal Behavior
Signaling
Cellular Response To Hormone Stimulus
Cell Communication
Cellular Response To Glucagon Stimulus
Signaling
Cell Communication
Energy Reserve Metabolic Process
G-protein Coupled Receptor Signaling Pathway
Response To Glucagon
Signal Transduction
Cell Surface Receptor Signaling Pathway
Energy Derivation By Oxidation Of Organic Compounds
Cellular Response To Stimulus
Response To Stimulus
Generation Of Precursor Metabolites And Energy
Cellular Response To Hormone Stimulus
Synaptic Transmission
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Response To Peptide
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Regulation Of Cellular Process
Response To Peptide Hormone
Cell-cell Signaling
Cellular Response To Organonitrogen Compound
Response To Hormone
Cellular Response To Organic Substance
Response To Organic Substance
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Response To Organonitrogen Compound
Regulation Of Signaling
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of CAMP Metabolic Process
Regulation Of Adenylate Cyclase Activity
Regulation Of Signal Transduction
Regulation Of Cyclase Activity
Oxidation-reduction Process
Regulation Of Muscle Contraction
Positive Regulation Of Metabolic Process
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Multicellular Organismal Response To Stress
Regulation Of CAMP Biosynthetic Process
Platelet Activation
Regulation Of Insulin Secretion
Chemical Homeostasis
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Peptide Hormone Secretion
Cellular Process
Adrenergic Receptor Signaling Pathway
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Vasoconstriction
Small Molecule Metabolic Process
Tagcloud
?
abl
alterations
bcr
bez235
braf
canonical
cdkn2a
clustered
coexpression
confer
dimer
disrupt
effectors
encoding
galpha
gbeta
gbetagamma
gnb2
i80
interface
k57
neoplasms
oncogenic
partly
substitution
subunits
targetable
v600k
variants
Tagcloud (Difference)
?
abl
alterations
bcr
bez235
braf
canonical
cdkn2a
clustered
coexpression
confer
dimer
disrupt
effectors
encoding
galpha
gbeta
gbetagamma
gnb2
i80
interface
k57
neoplasms
oncogenic
partly
substitution
subunits
targetable
v600k
variants
Tagcloud (Intersection)
?