AOX1

Gene Name		aldehyde oxidase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Aldehyde Oxidase Activity Xanthine Dehydrogenase Activity Iron Ion Binding UDP-N-acetylmuramate Dehydrogenase Activity Electron Carrier Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding NAD Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Inflammatory Response Vitamin B6 Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Reactive Oxygen Species Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Vitamins B6 activation to pyridoxal phosphate Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS		Intelligence ( 22449649)
Protein-protein Interactions		5 interactors: ABCA1 CRKL GK RBL1 RCHY1
Entrez ID		316
HPRD ID		07537
Ensembl ID		ENSG00000138356
Uniprot IDs		B4DNI5 Q06278
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycerol-3-phosphate Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Interleukin-1 Beta Secretion Glycerol Catabolic Process Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Positive Regulation Of Metabolic Process Alcohol Metabolic Process Parathyroid Gland Development Platelet Dense Granule Organization Regulation Of Phosphorus Metabolic Process Phospholipid Efflux Glycerol-3-phosphate Metabolic Process Phagocytosis, Engulfment Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Response To Organic Substance Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cdc42 Protein Signal Transduction Cellular Carbohydrate Catabolic Process Glycerol Metabolic Process Cytokine Secretion Response To Fluid Shear Stress Regulation Of Cholesterol Transport Secretory Granule Organization Protein Autoubiquitination Triglyceride Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Anion Homeostasis
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