BACE2 and GGA2

Number of citations of the paper that reports this interaction (PMID 12135764)
28

Data Source:
BioGRID (unspecified method, pull down)

		BACE2	GGA2
Gene Name		beta-site APP-cleaving enzyme 2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Cell Surface Integral Component Of Membrane	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex Clathrin-coated Vesicle
	Molecular Function	Aspartic-type Endopeptidase Activity	Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process	Intracellular Protein Transport Vesicle-mediated Transport
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP GGA1 GGA2	30 interactors: AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC GGA1 GGA3 HGS HTT IGF2R LRP3 M6PR PIN1 RAB5A RABEP1 RABGEF1 RNF11 SORL1 SORT1 SPG21 STAB1 SYNRG TRIM23 VPS18
Entrez ID		25825	23062
HPRD ID		05744	09347
Ensembl ID		ENSG00000182240	ENSG00000103365
Uniprot IDs		Q9Y5Z0	Q9UJY4
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB	1MHQ
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Synaptic Growth At Neuromuscular Junction Intracellular Transport Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Establishment Of Localization In Cell Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Localization Neuron Remodeling Cellular Copper Ion Homeostasis	Vesicle-mediated Transport Endocytosis Intracellular Transport Protein Transport Establishment Of Protein Localization Transport Establishment Of Localization In Cell Protein Localization Cellular Localization Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Lysosomal Transport Golgi Vesicle Transport Vacuolar Transport Cellular Protein Localization Endosomal Transport Regulation Of Vesicle-mediated Transport Endosome To Lysosome Transport Cytoplasmic Transport Visual Learning Membrane Organization Visual Behavior Protein Targeting To Lysosome Protein Localization To Lysosome Associative Learning Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Signaling Protein Targeting To Vacuole Copper Ion Homeostasis Cell Communication Negative Regulation Of Signaling Establishment Of Protein Localization To Vacuole Learning Transition Metal Ion Homeostasis Membrane Protein Proteolysis Regulation Of Exocytosis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Synaptic Plasticity Regulation Of Protein Catabolic Process Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Phosphorylation Neural Plate Formation Negative Regulation Of Kit Signaling Pathway Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Tau-protein Kinase Activity Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Choline O-acetyltransferase Activity
Tagcloud ?		alleviate amounts angiogenesis anthocyanins apaf1 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially	addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Difference) ?		alleviate amounts angiogenesis anthocyanins apaf1 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially	addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Intersection) ?