BACE2 and PCM1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		BACE2	PCM1
Description		beta-secretase 2	pericentriolar material 1
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Protein Processing Peptide Hormone Processing Melanosome Organization Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid-beta Metabolic Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)	Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		5 interacting genes: APP GGA1 GGA2 PCM1 SNRNP70	57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830
Entrez ID		25825	5108
HPRD ID		05744	02624
Ensembl ID		ENSG00000182240	ENSG00000078674
Uniprot IDs		Q9Y5Z0	A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1 7D5B 7D5U 7F1G 7N4N	6HYL 6HYM 7Q46
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Folding	Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly
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