SPDEF and NKX3-1

Number of citations of the paper that reports this interaction (PMID 11809674)
20

Data Source:
HPRD (in vivo, two hybrid)

		SPDEF	NKX3-1
Gene Name		SAM pointed domain containing ETS transcription factor	NK3 homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Intracellular Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Androgen Receptor Activity Protein Binding Transcription Factor Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Estrogen Receptor Activity Protein Kinase Activator Activity Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Self-association Transcription Regulatory Region DNA Binding MADS Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development	Metanephros Development Somitogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organismal Development Salivary Gland Development Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Androgen Receptor Signaling Pathway Response To Testosterone Cellular Response To Drug Dorsal Aorta Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Hormone Mediated Signaling Pathway Protein Kinase B Signaling Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Steroid Hormone Stimulus Cellular Response To Hypoxia Mitotic Cell Cycle Arrest Negative Regulation Of Estrogen Receptor Binding Positive Regulation Of Androgen Secretion Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AR NKX3-1 PCGF2 STK11	32 interactors: AEN CCT7 CHPF CKAP4 FEM1B HIPK2 HMG20B HNRNPA0 HSP90B1 LMCD1 MAN2B1 MNAT1 ND4 PEBP1 PTMS RABL6 RARG RPL37A RPSA SP1 SP2 SP3 SP4 SP5 SPDEF SRF STMN3 STRA13 TEX264 TOPORS TPT1 WDR77
Entrez ID		25803	4824
HPRD ID		12176	03620
Ensembl ID		ENSG00000124664	ENSG00000167034
Uniprot IDs		O95238	Q99801
PDB IDs		1YO5 2DKX	2L9R
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Cellular Response To Hormone Stimulus Steroid Hormone Mediated Signaling Pathway Developmental Process Involved In Reproduction Negative Regulation Of Integrin Biosynthetic Process TCR Signalosome Assembly Negative Regulation Of Epithelial Cell Proliferation Response To Lipid Positive Regulation Of Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Cell Cycle Arrest Response To Hormone Organ Development Regulation Of Signaling Positive Regulation Of Androgen Secretion Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Signaling Single Organism Reproductive Process Regulation Of Integrin Biosynthetic Process Regulation Of Phosphorylation Reproductive Process Anterior/posterior Pattern Specification Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Epithelial Cell Proliferation Regulation Of Apoptotic Process Sex Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation System Development Cellular Response To Stress Anoikis Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Cellular Response To UV-B Negative Regulation Of Receptor Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Urogenital System Development Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase III Promoter Dorsal Aorta Development	Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Embryonic Eye Morphogenesis Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Embryonic Camera-type Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Eye Morphogenesis Biosynthetic Process Megakaryocyte Differentiation Trophectodermal Cell Differentiation Camera-type Eye Development Eye Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Erythrocyte Differentiation Erythrocyte Homeostasis Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Camera-type Eye Morphogenesis Organ Morphogenesis Myeloid Cell Homeostasis Organ Development Embryonic Organ Development Glandular Epithelial Cell Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Embryonic Process Involved In Female Pregnancy Sensory Organ Development Prostate Gland Development Regulation Of RNA Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Tissue Development System Development Homeostasis Of Number Of Cells
Tagcloud ?		accordingly airway arg arginine backgrounds bcl carcinogenesis chronically define determinant display displays driver ets hypersecretion metaplasia mucous p53 pointed prd proline prolines replacement sam substitution suppressing sustains untranslated utr
Tagcloud (Difference) ?		accordingly airway arg arginine backgrounds bcl carcinogenesis chronically define determinant display displays driver ets hypersecretion metaplasia mucous p53 pointed prd proline prolines replacement sam substitution suppressing sustains untranslated utr
Tagcloud (Intersection) ?