SPDEF and COX5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPDEF	COX5A
Description		SAM pointed domain containing ETS transcription factor	cytochrome c oxidase subunit 5A
Image
GO Annotations	Cellular Component	Chromatin Nucleus	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glandular Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development Epithelial Cell Fate Commitment	Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Proton Transmembrane Transport
Pathways			TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly
Drugs			Cholic Acid N-Formylmethionine
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Weight ( 28552196)	Caffeine consumption ( 21490707) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		13 interacting genes: AR CDK11A CEP57 COX5A ENKD1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23	9 interacting genes: COPS6 EPM2A EXOSC8 HTRA1 KRT31 KRT40 MESD MT-CO1 SPDEF
Entrez ID		25803	9377
HPRD ID		12176	04799
Ensembl ID		ENSG00000124664	ENSG00000178741
Uniprot IDs		O95238	P20674
PDB IDs		1YO5 2DKX	5Z62
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Proliferation Regulation Of Reproductive Process Nuclear Receptor Activity Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Epithelial Cell Proliferation Involved In Prostate Gland Development Estrogen Response Element Binding Branching Involved In Prostate Gland Morphogenesis Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Nuclear Receptor-mediated Signaling Pathway Male Gonad Development Androgen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Gonad Development Negative Regulation Of Epithelial Cell Proliferation Hormone-mediated Signaling Pathway Steroid Binding 14-3-3 Protein Binding Reproductive Structure Development Nuclear Estrogen Receptor Binding Developmental Process Involved In Reproduction Response To Testosterone Regulation Of Apoptotic Process Prostate Induction Regulation Of Programmed Cell Death Organ Growth Transcription Coactivator Binding Intracellular Receptor Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Androgen Secretion MADS Box Domain Binding Regulation Of Morphogenesis Of A Branching Structure Cytoplasmic Microtubule Chromatin Response To Estrogen Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Dorsal Aorta Development Centrosome Regulation Of MiRNA Transcription ATPase Binding Lipid Binding	Epithelial Cell Differentiation Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Dibenzo-p-dioxin Metabolic Process Arachidonate Monooxygenase Activity Response To Copper Ion Coumarin Metabolic Process Insecticide Metabolic Process Response To Diphenyl Ether Developmental Process Ethylene Metabolic Process Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Negative Regulation Of Phosphatase Activity Carbohydrate Phosphatase Activity Starch Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Lung Goblet Cell Differentiation Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Heme Binding Response To Iron(III) Ion Demethylase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity Habituation Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Glandular Epithelial Cell Development Long-chain Fatty Acid Omega-hydroxylase Activity Response To Phenylpropanoid Retinoic Acid Biosynthetic Process Lipid Hydroxylation Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Intermediate Filament Chorionic Trophoblast Cell Differentiation Nonassociative Learning Negative Regulation Of Dephosphorylation Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Exoribonuclease Complex
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