SPDEF and PCGF2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		SPDEF	PCGF2
Gene Name		SAM pointed domain containing ETS transcription factor	polycomb group ring finger 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Anterior/posterior Pattern Specification Protein Ubiquitination Histone Acetylation Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AR NKX3-1 PCGF2 STK11	23 interactors: ABHD6 CBX6 CBX7 CBX8 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		25803	7703
HPRD ID		12176	10621
Ensembl ID		ENSG00000124664	ENSG00000056661
Uniprot IDs		O95238	P35227
PDB IDs		1YO5 2DKX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Cellular Response To Hormone Stimulus Steroid Hormone Mediated Signaling Pathway Developmental Process Involved In Reproduction Negative Regulation Of Integrin Biosynthetic Process TCR Signalosome Assembly Negative Regulation Of Epithelial Cell Proliferation Response To Lipid Positive Regulation Of Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Cell Cycle Arrest Response To Hormone Organ Development Regulation Of Signaling Positive Regulation Of Androgen Secretion Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Signaling Single Organism Reproductive Process Regulation Of Integrin Biosynthetic Process Regulation Of Phosphorylation Reproductive Process Anterior/posterior Pattern Specification Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Epithelial Cell Proliferation Regulation Of Apoptotic Process Sex Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation System Development Cellular Response To Stress Anoikis Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Cellular Response To UV-B Negative Regulation Of Receptor Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Urogenital System Development Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase III Promoter Dorsal Aorta Development	Histone Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Chromatin Modification Chromatin Organization Protein Polyubiquitination Histone Modification Chromosome Organization Protein K48-linked Ubiquitination Protein Monoubiquitination Histone H2A Monoubiquitination Cellular Protein Modification Process Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Histone Monoubiquitination Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Sterol Regulatory Element Binding Protein Import Into Nucleus RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Anterior/posterior Pattern Specification Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Catabolic Process Regulation Of Gene Expression Protein Linear Polyubiquitination Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Tagcloud ?		accordingly airway arg arginine backgrounds bcl carcinogenesis chronically define determinant display displays driver ets hypersecretion metaplasia mucous p53 pointed prd proline prolines replacement sam substitution suppressing sustains untranslated utr	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Difference) ?		accordingly airway arg arginine backgrounds bcl carcinogenesis chronically define determinant display displays driver ets hypersecretion metaplasia mucous p53 pointed prd proline prolines replacement sam substitution suppressing sustains untranslated utr	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Intersection) ?