SPDEF and PCGF2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		SPDEF	PCGF2
Description		SAM pointed domain containing ETS transcription factor	polycomb group ring finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glandular Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development Epithelial Cell Fate Commitment	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways			SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		13 interacting genes: AR CDK11A CEP57 COX5A ENKD1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23	26 interacting genes: ABHD6 AKT1 CBX6 CCND2 CD247 CDK2 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RNF2 SPDEF STX2 SUMO3 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		25803	7703
HPRD ID		12176	10621
Ensembl ID		ENSG00000124664	ENSG00000277258
Uniprot IDs		O95238	P35227
PDB IDs		1YO5 2DKX
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Proliferation Regulation Of Reproductive Process Nuclear Receptor Activity Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Epithelial Cell Proliferation Involved In Prostate Gland Development Estrogen Response Element Binding Branching Involved In Prostate Gland Morphogenesis Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Nuclear Receptor-mediated Signaling Pathway Male Gonad Development Androgen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Gonad Development Negative Regulation Of Epithelial Cell Proliferation Hormone-mediated Signaling Pathway Steroid Binding 14-3-3 Protein Binding Reproductive Structure Development Nuclear Estrogen Receptor Binding Developmental Process Involved In Reproduction Response To Testosterone Regulation Of Apoptotic Process Prostate Induction Regulation Of Programmed Cell Death Organ Growth Transcription Coactivator Binding Intracellular Receptor Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Androgen Secretion MADS Box Domain Binding Regulation Of Morphogenesis Of A Branching Structure Cytoplasmic Microtubule Chromatin Response To Estrogen Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Dorsal Aorta Development Centrosome Regulation Of MiRNA Transcription ATPase Binding Lipid Binding	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Transferase Activity TORC1 Signaling Protein Metabolic Process Protein K6-linked Ubiquitination TOR Signaling Protein K48-linked Ubiquitination Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein K29-linked Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Metabolic Process Regulation Of Protein Localization PRC1 Complex Positive Regulation Of Protein Localization To Cell Surface Ubiquitin-like Protein Transferase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Response To Nitric Oxide Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Cycle Phase Transition PcG Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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