SPDEF and STK11

Number of citations of the paper that reports this interaction (PMID 16912160)
14

Data Source:
BioGRID (two hybrid)

		SPDEF	STK11
Gene Name		SAM pointed domain containing ETS transcription factor	serine/threonine kinase 11
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Mitochondrion Cytosol Membrane TCR Signalosome Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Energy Reserve Metabolic Process Protein Phosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatid Development Axonogenesis Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Ionizing Radiation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Response To Glucagon Response To Lipid TCR Signalosome Assembly Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Anoikis Small Molecule Metabolic Process Positive Thymic T Cell Selection Positive Regulation Of Gluconeogenesis Protein Autophosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Protein Heterooligomerization Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS			Alzheimer's disease ( 22005930)
Protein-Protein Interactions		4 interactors: AR NKX3-1 PCGF2 STK11	29 interactors: APP ATM CAB39 CDC37 ETV4 MAPRE1 MARK1 MARK2 MARK4 MOB4 PARD3 PRKAA1 PRKAA2 PRKACA PTEN RPS6KA3 RPS6KA5 RPS6KB1 SIK1 SIRT1 SMARCA4 SNRK SPDEF STK11IP STRADA STRADB TNIP2 TP53 UBE2D2
Entrez ID		25803	6794
HPRD ID		12176	03740
Ensembl ID		ENSG00000124664	ENSG00000118046
Uniprot IDs		O95238	Q15831
PDB IDs		1YO5 2DKX	2WTK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Prostate Gland Development Cellular Response To Hormone Stimulus Steroid Hormone Mediated Signaling Pathway Developmental Process Involved In Reproduction Negative Regulation Of Integrin Biosynthetic Process TCR Signalosome Assembly Negative Regulation Of Epithelial Cell Proliferation Response To Lipid Positive Regulation Of Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Cell Cycle Arrest Response To Hormone Organ Development Regulation Of Signaling Positive Regulation Of Androgen Secretion Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Signaling Single Organism Reproductive Process Regulation Of Integrin Biosynthetic Process Regulation Of Phosphorylation Reproductive Process Anterior/posterior Pattern Specification Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Epithelial Cell Proliferation Regulation Of Apoptotic Process Sex Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation System Development Cellular Response To Stress Anoikis Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Cellular Response To UV-B Negative Regulation Of Receptor Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Urogenital System Development Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase III Promoter Dorsal Aorta Development	Regulation Of Cell Cycle Protein Phosphorylation Cell Cycle Cellular Protein Modification Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Arrest Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Cell Death Histone Phosphorylation Regulation Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Cellular Response To Organic Substance Regulation Of Protein Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Protein Metabolic Process Cell Differentiation Signaling Response To Insulin Response To Peptide Hormone Cell Communication Response To External Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Regulation Of Signal Transduction
Tagcloud ?		accordingly airway arg arginine backgrounds bcl carcinogenesis chronically define determinant display displays driver ets hypersecretion metaplasia mucous p53 pointed prd proline prolines replacement sam substitution suppressing sustains untranslated utr	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Difference) ?		accordingly airway arg arginine backgrounds bcl carcinogenesis chronically define determinant display displays driver ets hypersecretion metaplasia mucous p53 pointed prd proline prolines replacement sam substitution suppressing sustains untranslated utr	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Intersection) ?