SPDEF

Description		SAM pointed domain containing ETS transcription factor
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GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glandular Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development Epithelial Cell Fate Commitment
Pathways
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Weight ( 28552196)
Novel Interacting Genes		1 novel interacting genes: ESR1
Interacting Genes		13 interacting genes: AR CDK11A CEP57 COX5A ENKD1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23
Entrez ID		25803
HPRD ID		12176
Ensembl ID		ENSG00000124664
Uniprot IDs		O95238
PDB IDs		1YO5 2DKX
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Proliferation Regulation Of Reproductive Process Nuclear Receptor Activity Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Epithelial Cell Proliferation Involved In Prostate Gland Development Estrogen Response Element Binding Branching Involved In Prostate Gland Morphogenesis Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Nuclear Receptor-mediated Signaling Pathway Male Gonad Development Androgen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Gonad Development Negative Regulation Of Epithelial Cell Proliferation Hormone-mediated Signaling Pathway Steroid Binding 14-3-3 Protein Binding Reproductive Structure Development Nuclear Estrogen Receptor Binding Developmental Process Involved In Reproduction Response To Testosterone Regulation Of Apoptotic Process Prostate Induction Regulation Of Programmed Cell Death Organ Growth Transcription Coactivator Binding Intracellular Receptor Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Androgen Secretion MADS Box Domain Binding Regulation Of Morphogenesis Of A Branching Structure Cytoplasmic Microtubule Chromatin Response To Estrogen Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Dorsal Aorta Development Centrosome Regulation Of MiRNA Transcription ATPase Binding Lipid Binding
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