GABRR2 and GABRR1

Number of citations of the paper that reports this interaction (PubMedID 9153229)
0

Data Source:
HPRD (in vitro)

		GABRR2	GABRR1
Description		gamma-aminobutyric acid type A receptor subunit rho2	gamma-aminobutyric acid type A receptor subunit rho1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Intracellular Vesicle GABA-ergic Synapse GABA-A Receptor Complex	Plasma Membrane Membrane Chloride Channel Complex Presynaptic Membrane Synapse Postsynaptic Membrane Intracellular Vesicle Glutamatergic Synapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Domain Specific Binding GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity Protein Domain Specific Binding GABA-gated Chloride Ion Channel Activity Identical Protein Binding Protein-containing Complex Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Visual Perception Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Synaptic Transmission, GABAergic Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport
Pathways		GABA receptor activation	GABA receptor activation
Drugs		Fludiazepam TPMPA	Lindane Picrotoxin Fludiazepam TPMPA
Diseases
GWAS		Systemic lupus erythematosus ( 32771030) Third ventricle volume ( 31530798)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder and schizophrenia ( 20889312) Diabetic kidney disease in type 2 diabetes ( 29703844) Early diabetic kidney disease in type 2 diabetes ( 29703844) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)
Interacting Genes		5 interacting genes: CSNK2A1 GABRR1 MAP1B PRKCA SQSTM1	10 interacting genes: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1
Entrez ID		2570	2569
HPRD ID		15922	15921
Ensembl ID		ENSG00000111886	ENSG00000146276
Uniprot IDs		B4DER2 P28476	P24046
PDB IDs			8OP9 8OQ6 8OQ7 8OQ8 8OQA 8RH4 8RH7 8RH8 8RH9 8RHG
Enriched GO Terms of Interacting Partners?		Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Regulation Of Biological Quality Protein Targeting To Vacuole Protein-containing Complex Binding Protein Catabolic Process Protein Localization To Vacuole Establishment Of Protein Localization To Vacuole Regulation Of Cell Communication Regulation Of Signaling PML Body Negative Regulation Of Protein Metabolic Process Glutamatergic Synapse Modulation Of Chemical Synaptic Transmission Response To Estradiol Induction Of Synaptic Plasticity By Chemical Substance Response To Toxic Substance Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Brown Fat Cell Proliferation Amphisome Positive Regulation Of Cell Growth Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Macroautophagy Regulation Of Synapse Assembly Axonogenesis Hippocampal Mossy Fiber Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Vacuolar Transport Positive Regulation Of Autophagy Negative Regulation Of Translation Protein Kinase C Signaling Cell Death Apoptotic Process Protein Targeting Negative Regulation Of Programmed Cell Death Positive Regulation Of Aggrephagy Programmed Cell Death Synapse Response To Mechanical Stimulus Regulation Of Synaptic Plasticity Basal Dendrite Regulation Of Angiotensin-activated Signaling Pathway Cellular Component Assembly GABA Receptor Activity Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Lewy Body	Regulation Of Biological Quality Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity System Process Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Localization Kinase Activity Regulation Of Steroid Biosynthetic Process Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Regulation Of Steroid Metabolic Process Protein Phosphorylation ATP Binding Plasma Membrane Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Synapse Regulation Of Transport Response To Carbohydrate Positive Regulation Of Cholesterol Metabolic Process Regulation Of Platelet Aggregation Regulation Of Cholesterol Biosynthetic Process Nucleotide Binding Regulation Of Lipid Biosynthetic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Synaptic Plasticity Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Postsynapse Protein Catabolic Process Dendrite Development Regulation Of Intracellular Signal Transduction Regulation Of Muscle System Process Sperm Midpiece Regulation Of Cholesterol Metabolic Process Protein Targeting To Vacuole Cell Communication Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Intracellular Transport Regulation Of Platelet Activation Positive Regulation Of Calcium-mediated Signaling Response To Stress Induction Of Synaptic Plasticity By Chemical Substance
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