GABRR2 and MAP1B

Number of citations of the paper that reports this interaction (PubMedID 11102469)
51

Data Source:
HPRD (in vitro)

		GABRR2	MAP1B
Description		gamma-aminobutyric acid type A receptor subunit rho2	microtubule associated protein 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Intracellular Vesicle GABA-ergic Synapse GABA-A Receptor Complex	Photoreceptor Outer Segment Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Axon Dendrite Growth Cone Somatodendritic Compartment Cell Projection Neuronal Cell Body Varicosity Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Basal Dendrite Hippocampal Mossy Fiber Postsynapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Domain Specific Binding GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Actin Binding Structural Molecule Activity Protein Binding Phospholipid Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Visual Perception Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Negative Regulation Of Microtubule Depolymerization Nervous System Development Axonogenesis Synapse Assembly Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Carbohydrate Peripheral Nervous System Axon Regeneration Dendrite Development Response To Insecticide Developmental Maturation Regulation Of Microtubule Depolymerization Positive Regulation Of Microtubule Polymerization Neuron Projection Development Response To Nutrient Levels Response To Estradiol Negative Regulation Of Intracellular Transport Response To Vitamin A Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Intracellular Transport Mitochondrion Transport Along Microtubule Neuron Development Axon Extension Response To Axon Injury Induction Of Synaptic Plasticity By Chemical Substance Establishment Of Monopolar Cell Polarity Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Odontoblast Differentiation Regulation Of Postsynapse Assembly
Pathways		GABA receptor activation	RSV-host interactions
Drugs		Fludiazepam TPMPA
Diseases
GWAS		Systemic lupus erythematosus ( 32771030) Third ventricle volume ( 31530798)	Attention deficit hyperactivity disorder ( 18839057) Coronary artery disease in type 1 diabetes ( 29695241) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: CSNK2A1 GABRR1 MAP1B PRKCA SQSTM1	36 interacting genes: ACTB ANP32A ARHGEF11 CREBBP CSNK2A1 DYNLL1 EEF1D ERBB3 FOS GABRR1 GABRR2 GAN GSK3B HMGB1 HTR6 LRRK2 MAG MAGOH MAP1A MAPK8 MARCHF5 MINK1 NEIL3 NXF1 NXF2 PAFAH1B1 PRKAR1A RASSF1 RNF10 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2 VHL
Entrez ID		2570	4131
HPRD ID		15922	01139
Ensembl ID		ENSG00000111886	ENSG00000131711
Uniprot IDs		B4DER2 P28476	A2BDK6 P46821 Q6PJD3 Q86X89
PDB IDs
Enriched GO Terms of Interacting Partners?		Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Regulation Of Biological Quality Protein Targeting To Vacuole Protein-containing Complex Binding Protein Catabolic Process Protein Localization To Vacuole Establishment Of Protein Localization To Vacuole Regulation Of Cell Communication Regulation Of Signaling PML Body Negative Regulation Of Protein Metabolic Process Glutamatergic Synapse Modulation Of Chemical Synaptic Transmission Response To Estradiol Induction Of Synaptic Plasticity By Chemical Substance Response To Toxic Substance Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Brown Fat Cell Proliferation Amphisome Positive Regulation Of Cell Growth Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Macroautophagy Regulation Of Synapse Assembly Axonogenesis Hippocampal Mossy Fiber Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Vacuolar Transport Positive Regulation Of Autophagy Negative Regulation Of Translation Protein Kinase C Signaling Cell Death Apoptotic Process Protein Targeting Negative Regulation Of Programmed Cell Death Positive Regulation Of Aggrephagy Programmed Cell Death Synapse Response To Mechanical Stimulus Regulation Of Synaptic Plasticity Basal Dendrite Regulation Of Angiotensin-activated Signaling Pathway Cellular Component Assembly GABA Receptor Activity Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Lewy Body	Tau Protein Binding Positive Regulation Of Cell Communication Cellular Response To Stress Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Microtubule Associated Complex Axon Regulation Of Norepinephrine Uptake Regulation Of Biological Quality JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Transporter Regulator Activity Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Localization Negative Regulation Of Gene Expression Synapse Glutamatergic Synapse Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Protein Localization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Pre-mRNA 3'-splice Site Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Trans-synaptic Signaling Synaptic Signaling Modulation Of Chemical Synaptic Transmission Nuclear RNA Export Factor Complex Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Substantia Nigra Development Regulation Of Apoptotic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process
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