ITM2B

Description		integral membrane protein 2B
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Golgi-associated Vesicle Membrane Organelle Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protein Binding ATP Binding
	Biological Process	Nervous System Development Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		7 interacting genes: APP BCL2 CREB3 KASH5 LMNA NAALADL2 SYNE4
Entrez ID		9445
HPRD ID		04878
Ensembl ID		ENSG00000136156
Uniprot IDs		A0A384MDP7 Q9Y287
PDB IDs		8RNU
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Signaling Pathway Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Neuron Maturation Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway Nuclear Envelope Nuclear Outer Membrane Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Cell Migration Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Development Regulation Of Metal Ion Transport Regulation Of Cell Motility Identical Protein Binding Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cellular PH Reduction Striated Muscle Cell Development Positive Regulation Of Deacetylase Activity Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Chromosome Localization Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Supramolecular Fiber Organization Muscle Cell Development CD8-positive, Alpha-beta T Cell Lineage Commitment BAD-BCL-2 Complex Channel Inhibitor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Meiotic Spindle Pole PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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