KCTD13 and POLD2

Number of citations of the paper that reports this interaction (PMID 11593007)
7

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		KCTD13	POLD2
Gene Name		potassium channel tetramerization domain containing 13	polymerase (DNA directed), delta 2, accessory subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity GTP-Rho Binding Protein Domain Specific Binding Identical Protein Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA Replication Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways			Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ADRB2 ARMC7 CUL3 KAT7 LNX1 NUDT18 PCNA POLD2 PPARG RHOA TNFAIP1 VTA1 ZMYND19	16 interactors: CCHCR1 CDK2 CDKN1A EP300 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 SOX12 WRN WRNIP1 XRN1
Entrez ID		253980	5425
HPRD ID		12339	15982
Ensembl ID		ENSG00000174943	ENSG00000106628
Uniprot IDs		Q8WZ19	A4D2J4 B2R5S4 P49005
PDB IDs			3E0J
Enriched GO Terms of Interacting Partners?		DNA Replication Stress Fiber Assembly Regulation Of DNA Replication Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Negative Regulation Of Rho Protein Signal Transduction Telomere Maintenance Via Recombination Protein Complex Assembly Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cytokinesis Transcription-coupled Nucleotide-excision Repair Brown Fat Cell Differentiation Mitotic Cell Cycle Response To Cold Regulation Of Cytokinesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Mismatch Repair Base-excision Repair Actin Filament Bundle Assembly Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process DGDP Catabolic Process DADP Catabolic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Positive Regulation Of Deoxyribonuclease Activity Response To Diuretic GDP Catabolic Process Telomere Maintenance Nucleotide-excision Repair Chromosome Organization Cell Cycle Process Leading Strand Elongation Regulation Of Cholesterol Transporter Activity Cellular Response To Vitamin E Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Cellular Component Assembly DNA Metabolic Process DNA-dependent DNA Replication Negative Regulation Of Signal Transduction DNA Biosynthetic Process Actomyosin Structure Organization Ubiquitin-dependent Protein Catabolic Process Organelle Organization Modification-dependent Protein Catabolic Process Skeletal Muscle Satellite Cell Migration	DNA Replication DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Base-excision Repair Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Telomere Maintenance Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Repair Mismatch Repair Chromosome Organization Cellular Response To Stress DNA Metabolic Process Mitotic Cell Cycle DNA Recombination Nucleotide-excision Repair Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Response To Stress Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Macromolecule Biosynthetic Process Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Response To UV Positive Regulation Of DNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Mitochondrion Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Biosynthetic Process
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