G6PD and SUMO4

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		G6PD	SUMO4
Description		glucose-6-phosphate dehydrogenase	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Membrane Centriolar Satellite Extracellular Exosome	Nucleus SUMO Ligase Complex
	Molecular Function	Glucose-6-phosphate Dehydrogenase Activity Protein Binding D-glucose Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Carbohydrate Binding Identical Protein Binding Protein Homodimerization Activity NADP Binding	Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Glucose Metabolic Process Pentose-phosphate Shunt Lipid Metabolic Process Cholesterol Biosynthetic Process NADP+ Metabolic Process NADPH Regeneration Glutathione Metabolic Process Pentose-phosphate Shunt, Oxidative Branch Response To Iron(III) Ion Pentose Biosynthetic Process Substantia Nigra Development Response To Food Cellular Response To Oxidative Stress Erythrocyte Maturation Regulation Of Neuron Apoptotic Process Response To Ethanol Ribose Phosphate Biosynthetic Process Glucose 6-phosphate Metabolic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Reactive Oxygen Species Metabolic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus
Pathways		TP53 Regulates Metabolic Genes Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs		Glycolic acid Nicotinamide adenine dinucleotide phosphate 16-Bromoepiandrosterone Artenimol
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Bilirubin levels ( 19419973) Glycated hemoglobin levels ( 28898252 31213470 34059833) Hemoglobin levels ( 26366553) hemolysis of donated blood (oxidative) ( 34014839) Mean corpuscular hemoglobin ( 28453575) Mean corpuscular volume ( 28453575) Red blood cell count ( 28453575) Red blood cell traits ( 23446634 23696099) Red cell distribution width ( 28453575)	Dupuytren's disease ( 28886342)
Interacting Genes		5 interacting genes: CDC42 LINC00624 LINC01554 PAK4 SUMO4	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		2539	387082
HPRD ID		02377	10584
Ensembl ID		ENSG00000160211	ENSG00000177688
Uniprot IDs		A0A384NL00 P11413	Q6EEV6
PDB IDs		1QKI 2BH9 2BHL 5UKW 6E07 6E08 6JYU 6VA0 6VA7 6VA8 6VA9 6VAQ 7SEH 7SEI 7SNF 7SNG 7SNH 7SNI 7TOE 7TOF 7UAG 7UAL 7UC2 7ZVD
Enriched GO Terms of Interacting Partners?			Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process
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