G6PD

Description		glucose-6-phosphate dehydrogenase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Glucose-6-phosphate Dehydrogenase Activity Protein Binding D-glucose Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Carbohydrate Binding Identical Protein Binding Protein Homodimerization Activity NADP Binding
	Biological Process	Glucose Metabolic Process Pentose-phosphate Shunt Lipid Metabolic Process Cholesterol Biosynthetic Process NADP+ Metabolic Process NADPH Regeneration Glutathione Metabolic Process Pentose-phosphate Shunt, Oxidative Branch Response To Iron(III) Ion Pentose Biosynthetic Process Substantia Nigra Development Response To Food Cellular Response To Oxidative Stress Erythrocyte Maturation Regulation Of Neuron Apoptotic Process Response To Ethanol Ribose Phosphate Biosynthetic Process Glucose 6-phosphate Metabolic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		TP53 Regulates Metabolic Genes Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs		Glycolic acid Nicotinamide adenine dinucleotide phosphate 16-Bromoepiandrosterone Artenimol
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Bilirubin levels ( 19419973) Glycated hemoglobin levels ( 28898252 31213470 34059833) Hemoglobin levels ( 26366553) hemolysis of donated blood (oxidative) ( 34014839) Mean corpuscular hemoglobin ( 28453575) Mean corpuscular volume ( 28453575) Red blood cell count ( 28453575) Red blood cell traits ( 23446634 23696099) Red cell distribution width ( 28453575)
Interacting Genes		5 interacting genes: CDC42 LINC00624 LINC01554 PAK4 SUMO4
Entrez ID		2539
HPRD ID		02377
Ensembl ID		ENSG00000160211
Uniprot IDs		A0A384NL00 P11413
PDB IDs		1QKI 2BH9 2BHL 5UKW 6E07 6E08 6JYU 6VA0 6VA7 6VA8 6VA9 6VAQ 7SEH 7SEI 7SNF 7SNG 7SNH 7SNI 7TOE 7TOF 7UAG 7UAL 7UC2 7ZVD
Enriched GO Terms of Interacting Partners?
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